Medical Director (Nephrology)

Jade Biosciences•Boston, MA

6d•$270,000 - $300,000•Remote

About The Position

Jade Biosciences is focused on developing innovative, best-in-class therapies to address critical unmet needs in autoimmune diseases. Our lead candidate, JADE101, is designed to inhibit the cytokine APRIL (A Proliferation-Inducing Ligand) and is being developed for the treatment of immunoglobulin A nephropathy (IgAN), a chronic kidney disease that can impair kidney function over time. JADE101 aims to reduce harmful IgA antibodies, lower proteinuria (a key marker of kidney damage), and preserve long-term kidney function. A Phase 1 healthy-volunteer study of JADE101 is ongoing, with interim, biomarker-rich data expected in the first half of 2026. Jade’s pipeline also includes a second development candidate, JADE201, and an undisclosed antibody discovery program, JADE-003, both currently in preclinical development. For more information, visit JadeBiosciences.com and follow us on LinkedIn. We are seeking an experienced and mission-driven Medical Director to lead and support clinical programs in nephrology, with a focus on rare or immune-mediated kidney diseases. This role is ideal for a physician-scientist who thrives in a small biotech environment where agility, cross-functional collaboration, and scientific leadership are essential. The Medical Director will play a key role in advancing Jade’s pipeline through clinical development. This newly created position will report to the Executive Medical Director of Clinical Development. This is a fully remote role and will require some travel.

Requirements

MD (or equivalent medical degree); board certification in nephrology strongly preferred.
3+ years of experience as a nephrologist in academia or industry, and/or experience in nephrology clinical trials or rare disease programs.
Experience in clinical trial design, execution, and medical monitoring.
Strong clinical judgment, scientific rigor, and regulatory knowledge.
Ability to work independently and thrive in a fast-paced, matrixed environment.
Ability to manage multiple projects simultaneously and prioritize effectively in a fast-paced environment
Strong analytical, problem-solving, and decision-making skills
Excellent communication and interpersonal skills with the ability to influence and motivate cross-functional teams, manage a diverse set of stakeholders, and work closely with team leaders
High ethical standards and impeccable integrity
Exercise sound judgment in managing complex, confidential, and regulated information.

Responsibilities

Lead the design, execution, and oversight of clinical trials in nephrology, including protocol development, study monitoring, and data interpretation.
Serve as Medical Monitor for ongoing trials, ensuring patient safety and scientific integrity.
Collaborate with clinical operations, regulatory, and biometrics teams to ensure trial success and compliance.
Educate and advise clinical sites/investigators to support enrollment and optimal study conduct, including presenting at investigator meetings and/or site initiation visits, and serving as the medical point of contact for site staff questions about patient eligibility, and providing input into patient safety assessment and management
Provide medical expertise and support to external partners, vendors, and contractors as required to ensure smooth program execution
Communicate effectively, orally and in writing, with internal and external stakeholders regarding the assigned clinical program, including the CMO, CEO, external medical experts and others.
Contribute to the preparation of regulatory documents (INDs, NDAs, briefing documents, etc.).
Support interactions with regulatory authorities and ethics committees.
Stay current with scientific literature and competitive landscape in nephrology and related fields.
Partner with translational science, biomarker, and commercial teams to align clinical strategy with broader company goals.
Provide medical input into lifecycle planning and early market preparation.
Begin building relationships with key opinion leaders (KOLs), investigators, and advocacy groups in nephrology.
Represent the company at scientific meetings, advisory boards, and industry events.