Medical Director, Medical Affairs (Endocrine-Oncology) (Senior Director-Executive Director Level)

Rezolute•Redwood City, CA

4d•$250,000 - $290,000

About The Position

Rezolute is a late-stage rare disease biopharmaceutical company focused on developing transformative therapies for patients living with severe metabolic and endocrine disorders. Our mission is to bring hope and meaningful solutions to patients and families affected by rare and difficult-to-treat diseases through scientific innovation, collaboration, and integrity. Rezolute’s lead investigational therapy, RZ358 (ersodetug), is a fully human monoclonal antibody in late-stage clinical development for the treatment of hypoglycemia due to congenital and acquired forms of hyperinsulinism (HI). As Rezolute expands its medical and scientific focus into tumor-related hyperinsulinism (tumor HI), most commonly related to pancreatic neuroendocrine tumors (insulinomas) or paraneoplastic hypoglycemia (NICTH), the company is committed to advancing novel therapeutic strategies that address this rare and complex form of hypoglycemia associated with insulin-secreting tumors and related neuro-oncology disorders. Position Summary The Medical Director, Medical Affairs (Sr. Director- Executive Director) will serve as Rezolute’s internal medical and scientific expert in Endocrine-Oncology. This individual will play a pivotal role in developing and executing the Medical Affairs strategy that bridges oncology and endocrinology, advancing understanding and awareness of hypoglycemia in oncologic conditions. This role will lead internal disease-state and product education, guide cross-functional launch readiness, and provide scientific leadership for engagement with oncology and endocrinology key opinion leaders (KOLs). The Medical Director will partner closely with field-based Senior Medical Science Liaisons (MSLs) and colleagues across Clinical Development, Regulatory Affairs, Commercial, and Market Access to ensure scientific excellence, alignment, and execution across all medical initiatives. This position wil report to the Chief Medical Officer

Requirements

MD, DO, or equivalent advanced clinical degree, ideally with board certification or strong therapeutic expertise in Medical Oncology, Adult Endocrinology, or related medical specialties.
Demonstrated success developing and executing medical strategies for launch-stage or commercialized rare disease, oncology or endocrinology products .
Proven success in developing and executing medical strategies for launch-stage or rare oncology products.
Strong understanding of neuroendocrine tumor biology and relevant hypoglycemia conditions in the oncologic setting.
Proven experience in field-based Medical Affairs roles (such as Senior MSL or Medical Director) with extensive external scientific engagement responsibilities.
Proven ability to translate complex scientific data into clear, actionable insights.
Experience supporting MLR/PRC reviews or Medical Information processes preferred
Demonstrated collaboration skills in a fast-paced, matrixed organization.
Excellent communication, leadership, and presentation skills.
Willingness and ability to travel domestically and internationally (approximately up to 50%).

Nice To Haves

Minimum of 7 years of experience in Medical Affairs within the biopharmaceutical industry, ideally with experience in oncology, endocrine-oncology, or neuroendocrine tumors.
Prior experience supporting oncology or endocrinology product launches, particularly in rare tumor indications or metabolic-oncology interfaces.
Established professional relationships within oncology, endocrinology, and neuroendocrine communities.
Experience mentoring or leading field medical teams.
Experience supporting MLR/PRC reviews or Medical Information processes preferred
Strategic thinker with strong execution and organizational skills.
High integrity, accountability, and a deep commitment to Rezolute’s mission to improve the lives of patients with rare and complex diseases.

Responsibilities

Partner in shaping and delivering Rezolute’s Medical Affairs strategy in endocrine-oncology for RZ358 in treating hypoglycemia due to tumor-related hyperinsulinism (e.g. insulinomas and non-islet cell tumor hypoglycemia)
Serve as the internal disease area expert for hypoglycemia in the oncology setting, providing strategic input into launch readiness, data generation, and scientific communication.
Collaborate with Clinical Development and Commercial teams to ensure medical strategy supports both clinical evidence needs and market preparedness.
Contribute to the development of publication plans, data dissemination strategies, and scientific platforms.
Assist with integrating insights gathered from field interactions into Medical Affairs strategy, launch readiness plans, and scientific communication priorities.
Partner with senior medical leadership across the Company’s programs, to ensure consistent messaging, training, and field alignment across all medical initiatives.
Equip internal teams with the knowledge and confidence to meaningfully engage the medical and patient community through targeted disease and product education.
Function as the primary trainer for scientific and clinical content related to the pathophysiology of hyperinsulinism in neuroendocrine and non-islet cell tumors , RZ358 mechanism of action , clinical data, and competitive landscape.
Ensure internal teams are equipped to engage credibly and compliantly with healthcare professionals.
Mentor and coach MSLs to enhance their scientific expertise and strategic engagement capabilities.
Build and maintain strong peer-to-peer relationships with leading oncologists, neuroendocrine tumor specialists, and endocrinologists focused on tumor-related hypoglycemia.
Support the identification, engagement, and development of key opinion leaders (KOLs) and other external experts across oncology, endocrinology, and neuroendocrine disease communities.
Participate in and represent Rezolute at relevant oncology and endocrinology congresses, advisory boards, and symposia to communicate emerging science and gather medical insights.
Provide scientific leadership for investigator-initiated studies (IIS), data generation efforts, and collaborative research opportunities focused on hyperinsulinism.
Capture and synthesize medical insights from field teams and external experts to inform strategy, publications, and future development programs.
Collaborate with field-based MSLs and cross-functional launch teams to execute medical education, data dissemination, and stakeholder engagement plans for RZ358
Assist with the development of standard response documents and support Medical Information system execution.
Provide medical oversight for advisory board content, educational programs, and medical materials, ensuring scientific accuracy and compliance.
Provide ongoing scientific support to the Medical Information function through drafting, review, and refinement of standard response documents and FAQs.
Contribute to the development of scientific slide presentations, FAQs, and other materials for internal and external use.
Ensure all Medical Affairs activities adhere to Rezolute SOPs, regulatory standards, and applicable industry codes of practice.
Support medical/legal/regulatory (MLR) and promotional review activities, serving as a medical reviewer for scientific and promotional materials, ensuring accuracy, balance, and alignment with regulatory and compliance principles.
Support and partner cross-functionally with commercial pharmacovigilance to ensure safety reporting activities are alignment with health authority requirements and company policy.
Act as a visible ambassador for Rezolute’s mission, values, and ethical standards in all professional interactions.