Manager, Value Stream Cryo Operations

Bristol Myers Squibb • Summit, NJ

3d • Onsite

About The Position

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. At Bristol Myers Squibb we are reimagining the future of cell therapy. With our bold ambition, backed by a best-in-the-industry team and long-term commitment, we are leading the way to unlock the full promise of cell therapy as we strive to put more patients on the path to a cure. If you are ready to challenge yourself, accelerate your career, and give new hope to patients, there’s no better place than here at BMS with our Cell Therapy team. The Manager, CAR T Value Stream Cryo Operations leads a team of Specialists, Team Leads and Associates responsible for all processes associated with Cryopreservation and Sample Management, Frozen Process Material Retrieval, Movement, and Storage within CAR T clinical and commercial operations in a cGMP multi-cleanroom suite. This role plays a critical part in ensuring production continuity, traceability, and compliance across multiple shifts in a 24/7 operation. The Manager, is accountable for driving operational excellence, ensuring compliance with all regulatory requirements (FDA, DEA, DOT, ISBT, CTPAT, OSHA, VAWD, cGMPs), and fostering a culture of safety, collaboration, innovation, and continuous improvement. Shift Available: Wednesday - Saturday (with e/o Wednesday off), Onsite Overnight Shift, 5 p.m. - 5:30 a.m.

Requirements

• Advanced knowledge of cGMP/GDP/Pharmaceutical regulations and applications.
• Advanced knowledge of cryopreservation, material handling and logistics including best industry practices, application of principles, concepts, practices, standards, validation, and qualification.
• Strong knowledge and application of OSHA, DEA, USP and other applicable WH regulations.
• Proficiency in ERP systems / WMS Applications, MES and analytics tools.
• Proficiency in system and application use for business operations.
• Proficiency in MS Office applications.
• Proficiency in analytical, problem-solving, critical thinking skills and strong situational decision making.
• Proficient organizational and time management skills.
• Strong written and verbal communication skills.
• Intermediate presentation development and delivery skills.
• Ability to adapt to changing business conditions while maintaining appropriate level of controls and compliance with regulatory requirements.
• Ability to travel 10% of time.
• Bachelor’s degree in a relevant field (Life Sciences, Engineering, Operations). An equivalent combination of education and working experience to be considered.
• 5+ years of experience in biopharmaceutical manufacturing, cell therapy, or GMP operations.
• 2 years of leadership experience managing teams.
• Strong knowledge of cryopreservation, GMP documentation, and deviation management.
• Experience driving lean manufacturing principles and continuous improvement initiatives.

Responsibilities

• Lead Cryopreservation and handling of all Cell Therapy Products across multiple production areas and shifts.
• Ensure execution of production tasks in alignment with cGMPs, SOPs, and Work Instructions while maintaining complete traceability.
• Oversee Material Retrieval, Movement, Storage, and Inventory Management within Cryotanks and Controlled Rate Freezers (CRFs).
• Maintain hands-on expertise in Unit Operations, role model good execution and behaviors, and backfill resources if needed.
• Provide production scheduling team with daily, weekly, and monthly updates on resource availability and task execution.
• Lead batch record reviews (BRR) and ensure all documentation follows ALCOA+ principles.
• Drive adherence to all training requirements, ensuring team members are proficient and qualified.
• Recruit, train, and develop a high-performing team of Managers, Leads, and Associates.
• Set and adjust team priorities to align with site and functional objectives.
• Conduct regular 1:1 meetings to mentor and support team members’ professional development.
• Own the performance review process, provide continuous feedback, and recognize achievements.
• Foster a culture of accountability, ethics, and decision-making within the team.
• Champion lean principles to improve efficiency and eliminate non-value-added activities.
• Lead troubleshooting activities and own Deviation Management, ensuring timely documentation and closure.
• Monitor deviation metrics, identify repeat causes, and drive corrective actions.
• Participate in projects, change controls, and CAPAs to enhance compliance and operational performance.
• Participate and lead in process improvement projects withing the department.
• Build strong cross-functional relationships to drive collaboration and alignment with stakeholders.
• Control operational expenses (OT, Supplies, T&E) and identify cost-saving opportunities.
• Take personal responsibility for safety and hold the team accountable for safe practices.
• Perform regular safety Gemba walks, identify hazards, and drive corrective actions.
• Lead and participate in Tier 1/2/3 meetings, ensuring clear communication and problem resolution.
• Promote a culture of right-first-time execution, proactive issue resolution, and continuous learning.
• Champion a culture of compliance, operational discipline, and continuous improvement.
• Lead by example, demonstrating BMS core values: Inclusion, Accountability, Innovation, Urgency, and Passion.
• Drive root cause analysis and sustainable corrective actions to prevent recurrence of issues.
• Act as a change agent, promoting flexibility, creativity, and accountability in a fast-paced environment.
• Ensure knowledge sharing and cross-training across teams to build expertise.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Manager
• Number of Employees: 5,001-10,000 employees