LNP Intern
About The Position
We are seeking a motivated intern to apply their classroom knowledge in drug delivery, biomaterials, and formulation to contribute to developing delivery systems for LETI’s in vivo gene editing therapeutics in our state-of-the-art LNP delivery laboratory. This is a unique opportunity to gain hands-on experience and learn from seasoned drug delivery experts, with a focus on non-viral delivery technology development. Here’s What You’ll Do: The successful candidate will learn the workflow of our LNP delivery lab and shadow experienced scientists Execute established protocols, under supervision, and work on LNP production and downstream processing Characterize RNAs encapsulated LNPs for their size, zeta potential, encapsulation efficiency, integrity, and stability using conventional assays, e.g., dynamic light scattering (DLS), ribogreen assay, etc. Perform primary T-cell culture, transfection studies, and downstream flow cytometry analysis Adherence to good documentation practice Maintain data integrity and rigor Data entry into Benchling (electronic notebook) Generation of summary data with subsequent report Presentation at research meetings Attend Technology Development, cross-functional, and company meetings Why join Life Edit and the ElevateBio ecosystem? Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms – including Life Edit gene editing – and cGMP manufacturing to power the discovery and development of advanced therapeutics. Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives. Life Edit is an integral part of ElevateBio’s ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem. Our Mission: To power the creation of life-transforming cell and gene therapies, at a speed the world deserves. Our Vision: We seek to be the world’s most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated. ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Requirements
- Working towards a BSc, or BME degree in pharmaceutics, chemistry, bioengineering, or equivalent
- Organized, independent, and collaborative
- Excellent written and verbal communication skills
- Curiosity and diligence
Nice To Haves
- Hands-on experience with LNPs is preferred, but not required
Responsibilities
- Learn the workflow of our LNP delivery lab and shadow experienced scientists
- Execute established protocols, under supervision, and work on LNP production and downstream processing
- Characterize RNAs encapsulated LNPs for their size, zeta potential, encapsulation efficiency, integrity, and stability using conventional assays, e.g., dynamic light scattering (DLS), ribogreen assay, etc.
- Perform primary T-cell culture, transfection studies, and downstream flow cytometry analysis
- Adherence to good documentation practice
- Maintain data integrity and rigor
- Data entry into Benchling (electronic notebook)
- Generation of summary data with subsequent report
- Presentation at research meetings
- Attend Technology Development, cross-functional, and company meetings
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What This Job Offers
Career Level
Intern
