Lead Computational Toxicology Research Scientist - Chemical Insights Research Institute

UL Research Institutes•Morrisville, NC

1d•$119,260 - $163,983

About The Position

We have an exciting opportunity for a Lead Computational Toxicology Research Scientist at UL Research Institutes' Chemical Insights Research Institute, based in our Research Triangle Park, NC facilities. The The Lead Computational Toxicology Research Scientist conducts advanced computational research to support the Underwriters Laboratories Research Institutes’ Chemical Insights mission to provide unbiased research on chemicals and their risks to people’s health. This role focuses on building computational models that integrate, analyze, and interpret in vitro and in vivo toxicological data to assess potential human hazards and health risks. The Lead Computational Toxicology Research Scientist works closely with other internal scientists and external collaborators to deliver high-quality scientific outputs that inform chemical safety, risk assessment, regulatory policy, and public awareness. UL Research Institutes: At UL Research Institutes (ULRI), we expand the boundaries of safety science to create a more secure and sustainable world. For more than a century, we have studied the unintended consequences of innovation, designed solutions to mitigate risk and shared our findings with academia, scientists, manufacturers, and policymakers across industries. We identify critical safety and sustainability issues, asking the tough questions because we believe a safer world begins with knowledge. Build a safer, more secure, and sustainable future with us. Join us and work with our Chemical Insights team who conduct the research required to produce that knowledge and put into practice. Chemical Insights Research Institute (CIRI): The Chemical Insights Research Institute (CIRI) contributes to the protection of public health and well-being by conducting scientific research. Our research and initiatives let people around the world know what chemicals are in the air we breathe and how they affect human health and the planet. We share our research and knowledge through information and application tools with leaders in the scientific, business, and policy communities to raise awareness of human health risks stemming from emerging technologies. To learn more, visit: chemicalinsights.org/ What you’ll learn and achieve: As the Lead Computational Toxicology Research Scientist, you will play a key role in the rapid growth of UL as you: Design and execute computational toxicology studies aligned with ULRI’s Chemical Insights mission for understanding chemical safety. Develop and apply advanced computational toxicology methods that analyze, integrate, and interpret complex in vitro and in vivo toxicological and toxicokinetic data sets. Translate these in vitro screening data and toxicokinetic information into useful information for understanding systemic and targeted toxicities posed by chemical exposure. Apply and deepen knowledge of exploratory data analysis, statistics, machine learning to provide impactful analysis of data from new approach methods. Lead the development and application of data pipelines for targeted screening data and collaborate with other computational scientists on data pipelines for broad profiling data from transcriptomic and high content imaging experiments. Collaborate with cheminformatic and exposure scientists to help select chemicals for additional characterization, develop quantitative structure activity relationship models, and other cross-disciplinary tasks. Oversee extraction, curation, and quality evaluation of unstructured and structured data from in vivo toxicological studies, and help maintain reference databases of in vivo toxicological studies from diverse regulatory and non-regulatory sources. Collaborate with software developers and data engineers to incorporate in vitro and in vivo toxicological data sets into on-line dashboards and decision support tools. Collaborate with chemists, toxicologists, exposure scientists, statisticians, and other multidisciplinary team members to utilize in vitro toxicological data for chemical safety assessments. Provide technical expertise in study design, data interpretation, and quality assurance for computational toxicology projects. Stay current with emerging trends, technologies, and scientific literature in toxicology in order to lead new computational toxicology efforts. Present research findings at scientific conferences, stakeholder meetings, and technical forums. Continue to work in the computational toxicology field as a recognized expert. Serve as author on technical reports and peer-reviewed publications. Assist in writing research proposals and securing funding from internal and external sources. Perform other duties as assigned. What you’ll experience working at UL Research Institutes: We have pursued our mission of working for a safer, more secure, and sustainable world for nearly 130 years, embedding conscientious stewardship into everything we do. People: Our people make us special. You’ll work with a diverse team of experts respected for their independence and transparency and build a network, because our approach is collaborative. We collaborate across disciplines, organizations, and geographies to build the global scientific response that today’s global challenges require. Interesting work: Every day is different for us here. We see what’s on the horizon and use our expertise to build the foundations of a safer future. You’ll have the opportunity to push the boundaries of human understanding as part of a team working to advance the public good. Grow and achieve: We learn, work, and grow together through targeted development, reward, and recognition programs. Values. Four core values guide our work: collaboration, respect, integrity, and beneficence. By living our values, we inspire the trust essential to fulfilling our mission and foster the partnerships that enable us to pursue a beneficent future in which we all can thrive. Total Rewards: All employees at UL Research Institutes are eligible for bonus compensation. We offer comprehensive medical, dental, vision, and life insurance plans and a generous 401k matching structure of up to 5% of eligible pay. Moreover, we invest an additional 4% into your retirement saving fund after your first year of continuous employment. Depending on your role, you may be able to discuss flexible working arrangements with your manager. We also provide employees with paid time off, including vacation, holiday, sick, and volunteer days.

Requirements

Expert knowledge of in vitro and in vivo toxicology, computational toxicology, and chemical safety assessment.
Proficiency in computational modeling, statistics, and data analysis.
Demonstrated ability to independently conduct research and oversee all project phases from design to dissemination.
Demonstrated ability to work with laboratory scientists to turn raw data into normalized and transformed data that can be stored in databases.
Proven track record of publishing in peer-reviewed journals and presenting at scientific meetings.
Ability to clearly communicate complex toxicological, computational modeling, and chemical risk assessment concepts to diverse technical and non-technical audiences.
Demonstrated ability to influence research and special projects in the broader research community through national and international consortia.
Strong problem-solving skills and the ability to integrate computational toxicology data with broader public health research.
Ability to both lead and collaborate effectively in multidisciplinary teams.
Ph.D. in toxicology, environmental health, ecology, biology, or another related field, and
At least 6 years of relevant experience in computational toxicology and chemical safety assessment after completion of the Ph.D. by the start of the appointment.
Proven track record in developing computationally accessible data for toxicology and interpreting these data for chemical safety.
Demonstrated experience in the integration of high-throughput in vitro toxicity and toxicokinetic data and applying these concepts to chemical safety.

Responsibilities

Design and execute computational toxicology studies aligned with ULRI’s Chemical Insights mission for understanding chemical safety.
Develop and apply advanced computational toxicology methods that analyze, integrate, and interpret complex in vitro and in vivo toxicological and toxicokinetic data sets.
Translate these in vitro screening data and toxicokinetic information into useful information for understanding systemic and targeted toxicities posed by chemical exposure.
Apply and deepen knowledge of exploratory data analysis, statistics, machine learning to provide impactful analysis of data from new approach methods.
Lead the development and application of data pipelines for targeted screening data and collaborate with other computational scientists on data pipelines for broad profiling data from transcriptomic and high content imaging experiments.
Collaborate with cheminformatic and exposure scientists to help select chemicals for additional characterization, develop quantitative structure activity relationship models, and other cross-disciplinary tasks.
Oversee extraction, curation, and quality evaluation of unstructured and structured data from in vivo toxicological studies, and help maintain reference databases of in vivo toxicological studies from diverse regulatory and non-regulatory sources.
Collaborate with software developers and data engineers to incorporate in vitro and in vivo toxicological data sets into on-line dashboards and decision support tools.
Collaborate with chemists, toxicologists, exposure scientists, statisticians, and other multidisciplinary team members to utilize in vitro toxicological data for chemical safety assessments.
Provide technical expertise in study design, data interpretation, and quality assurance for computational toxicology projects.
Stay current with emerging trends, technologies, and scientific literature in toxicology in order to lead new computational toxicology efforts.
Present research findings at scientific conferences, stakeholder meetings, and technical forums.
Continue to work in the computational toxicology field as a recognized expert.
Serve as author on technical reports and peer-reviewed publications.
Assist in writing research proposals and securing funding from internal and external sources.
Perform other duties as assigned.

Benefits

All employees at UL Research Institutes are eligible for bonus compensation.
We offer comprehensive medical, dental, vision, and life insurance plans and a generous 401k matching structure of up to 5% of eligible pay.
Moreover, we invest an additional 4% into your retirement saving fund after your first year of continuous employment.
Depending on your role, you may be able to discuss flexible working arrangements with your manager.
We also provide employees with paid time off, including vacation, holiday, sick, and volunteer days.

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