In Vivo Pharmacology Scientist, Oncology Research

AstraZeneca • Gaithersburg, MD

153d • $87,200 - $130,800

About The Position

Are you ready to make a difference in the world of medicine? At AstraZeneca, we transform ideas into life-changing medicines. Our passion for science drives us to address the unmet needs of patients globally. We focus on areas where we can truly impact the course of medicine and bring groundbreaking ideas to life. Join us in our mission to push the boundaries of science in Oncology, aiming to change medical practices, transform patient lives, and ultimately eliminate cancer as a cause of death. We are developing a diverse pipeline of next-generation medicines targeting both solid and hematological cancers. We are looking for a motivated Scientist with expertise in in vivo oncology research to join our team in Gaithersburg, MD, USA. As a key member of our team, you will contribute to all aspects of in vivo pharmacology support, helping to establish assay systems and deliver impactful datasets for drug discovery.

Requirements

• B.S. in Biology, Pharmacology or related scientific discipline with 3-5+ years relevant scientific experience; M.S. - 1+ years MS desired but not required.
• Experience developing and working with complex in vivo animal models, such as syngeneic, human xenograft, and autochthonous rodent models.
• Proficient in numerous routes of drug administration - IV, IP, SC and PO.
• Capable of collecting blood samples via submandibular, tail vein or cardiac punctures.
• Experience executing in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies.
• Experience with a range of in vitro skills, e.g., cancer cell culture both suspension and adherent.
• Strong interpersonal and collaboration skills with evidence of delivering data packages in a team-oriented environment.
• Excellent communication and presentation skills.
• Proven track record of high productivity and scientific publications in peer-reviewed journals or IND enabled studies.

Nice To Haves

• Experience using biologics such as mAB, ADC, and small molecule in vivo preferred.
• Experience with multi-color Flowcytometry preferred.
• Proficient in RAT handling including blood drawing, cell implant, and IV dosing highly preferred.
• Experience handling human and mouse cell cultures in vitro proficiently with ability to scale up as needed.
• Demonstrated ability in presenting scientific results using GraphPad Prism and PowerPoint format.
• Knowledge of the industrial drug discovery process and ELN (electronic lab notebook) preferred.

Responsibilities

• Design, conduct, and analyze experiments to evaluate the function of our antibody drug conjugate (ADC) drugs and explore their mechanisms of action.
• Collaborate with cross-functional teams and project leaders to ensure timely data generation and dissemination.
• Contribute to scientific publication goals.
• Maintain a well-developed understanding of drug discovery approaches and apply broader functional knowledge to support diverse project groups.

Benefits

• 401(k) plan
• Paid vacation and holidays
• Paid leaves
• Health benefits including medical, prescription drug, dental, and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Industry: Chemical Manufacturing
• Education Level: Bachelor's degree