Histotechnologist

University Of Michigan (The Regents @ Ann Arbor)•Ann Arbor, MI

41d•Onsite

About The Position

The Biomedical Research Core Facilities is looking for a skilled Histotechnologist to join us in the Advanced Genomics Core. The incumbent will assist in developing, deploying, and executing protocols that improve spatial and single cell operations in the Advanced Genomics Core. Why Join Michigan Medicine? Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good. What Benefits can you Look Forward to? Excellent medical, dental and vision coverage effective on your very first day 2:1 Match on retirement savings

Requirements

A bachelors degree in biochemistry, cell biology, molecular biology or related biomedical field, or significant paid experience (8-10 years) in a Histotechnologist position with advanced knowledge in molecular biology skills, experience performing immunohistochemistry, immunofluorescence, cryo-sectioning, paraffin sectioning, Experience with various cell & tissue fixation methods.
Demonstrated experience in using and maintaining advanced automated laboratory equipment.
A successful candidate must have considerable hands-on experience in tissue and cell handling.
Proficiency and comfort with computer-based operations including standard office software (MS Word, MS Excel).
Must be meticulous at the lab bench and with record keeping in a LIMS or the MiCores system.
The ability to work independently and as part of a team in a diverse environment while under pressure to produce results in a timely manner is required.
Excellent written and spoken communication skills.

Nice To Haves

Experience with in-situ hybridization.

Responsibilities

Prepare samples for spatial transcriptomics experiments on animal and human tissue from client-provided samples.
Perform project specific techniques using instruments of advanced technologies including 10x Genomics Visium and Xenium platforms, expanding to additional related platforms in the future.
Responsibilities include embedding, sectioning, staining and imaging frozen or fixed tissue, primarily with H&E and DAPI.
Tasks may include but are not limited to inventory management, quality assessment, and efficiency enhancement.
Perform wet-bench techniques including recovery cryopreserved cells, cell viability assessment, cell/nuclei counting, assay processing, or others, while assuring that samples meet core quality requirements for further sample processing.
With direction from the Single Cell and Spatial Project manager communicate with clients regarding sample quality, performance, and assay parameters.
Document client requests electronically in LIMS and/or MiCores.
Communicate with other core facilities relevant to the analysis of spatial and single-cell specimens.