High-Throughput Functional Genomics (Discovery) Lead

Neptune Bio•New York, NY

13d

About The Position

We are seeking a visionary, hands-on scientific leader to drive our high-throughput functional genomics discovery platform. In this role, you will collaborate closely with experimental and computational teams across Neptune, manage and develop a high-performing group of scientists and research associates, and lead the onboarding and scale-up of next-generation single-cell screening technologies. You will serve as a technical authority in genomics technologies across the organization and play a central role in enabling large-scale screening for Neptune’s discovery engine—building a unique data moat that powers rapid and continuous target identification. The ideal candidate brings deep expertise in advanced single-cell CRISPR screening and sequencing technologies, combined with strong people leadership, project management experience, and a demonstrated ability to deliver large-scale projects under tight timelines. This role requires a highly collaborative, team-oriented mindset with a focus on generating high-quality results at speed. About You Scientific expert and team leader: You bring deep expertise in advanced single-cell and CRISPR screening technologies and have a strong track record of building and mentoring high-performing scientific teams through clear goals, execution, and guidance. Systems thinker and process optimizer: You think naturally at scale - building efficient workflows, and enabling large-volume research while balancing scientific rigor with operational demands. Results-driven: You thrive in fast-paced environments with tight deadlines, excel at prioritization, and consistently deliver complex projects on time within high-throughput settings.. Collaborative Team-player: You enjoy leading and mentoring a team of research scientists and associates, and you excel at working across experimental, computational, and operational teams to achieve shared goals. Adaptable learner: You stay current with emerging genomics technologies, apply sound judgment when adopting innovations, and can pivot strategies effectively to meet evolving organizational needs

Requirements

PhD, MD, or MD/PhD in genomics, biomedical engineering, molecular biology, or a related field, with training in high-throughput single-cell methodologies and next-generation sequencing
3–5+ years of relevant experience in academia, biotechnology, or the pharmaceutical industry
Prior experience in a leadership or mentorship role, with a demonstrated ability to manage and develop Ph.D. level scientists effectively
Proven record of delivering large, complex projects under tight deadlines in fast-paced, high-throughput environments
Demonstrated hands-on expertise and a strong, proven track record in genome engineering, CRISPR screening design, and high-throughput single-cell functional genomics
Deep expertise in molecular biology, biomedical engineering, high-content CRISPR screening, and single-cell genomics, supported by several years of academic or industry experience
Extensive knowledge of NGS library preparation workflows and the computational aspects of multi-omic profiling
Experience with a wide range of biological systems, including mammalian cell culture, primary cells, and complex cellular models (e.g., 3D organoid cultures and mouse models) relevant to biologics discovery
Experience with—or strong enthusiasm for—working at the interface of biology and data science, with the ability to collaborate effectively with AI/ML and computational scientists
Strong problem-solving abilities and an aptitude for innovation
Ability to adapt quickly to shifting priorities while delivering high-quality, detail-oriented results on time
A high degree of teamwork and a collaborative mindset, along with the ability to work independently

Nice To Haves

Industry experience post-PhD is desirable
Experience implementing process improvements and automation in production settings
Willingness to quickly discover and learn new methods and approaches
High motivation, with a strong work ethic and dedication to generating impact.
Experience with computational data handling, processing, and analysis
Long-term personal vision with defined career goals.
Outstanding written and verbal communication skills

Responsibilities

Act as a key individual contributor in a highly collaborative team, providing hands-on expertise in the lab to de-risk new technologies and scale up robust workflows for our high-throughput single-cell screening platform
Plan, manage, and execute a large-scale target discovery initiative focused on high-throughput single-cell CRISPR screening in vitro (2D and 3D) and in vivo
Manage multiple complex projects simultaneously, ensuring timely execution under tight deadlines
Lead, mentor, and manage a dedicated team of scientists and senior research associates, fostering a culture of innovation, collaboration, and scientific rigor
Spearhead the identification, evaluation, and implementation of cutting-edge technologies to enhance the speed, scale, and quality of our target discovery campaigns
Drive the design, execution, and optimization of sophisticated screening assays and technology development projects that directly impact program objectives
Develop and champion the strategic vision for technology innovation within our target discovery platform, staying current with rapidly evolving scientific fields and identifying, evaluating, and implementing new methodologies
Oversee experimental design, protocol development, and resource allocation across the target discovery platform to ensure project milestones and scientific objectives are met
Effectively analyze and present data, clearly communicating research plans, progress, and timelines to the team
Present scientific findings, project updates, and strategic proposals to internal and external stakeholders, contributing to publications and intellectual property filings
Collaborate closely with the CompBio team to build robust screening workflows, and maintain detailed, well-organized, and timely documentation of experiments and data