Head of Translational Oncology

Iambic Therapeutics, Inc•San Diego, CA

13d

About The Position

Iambic Therapeutics is seeking an exceptional scientific leader to serve as Head of Translational Oncology — a highly visible role at the intersection of discovery biology, clinical development, and AI/ML-driven drug development. This role is intentionally broader and more senior than traditional translational biology leadership positions. In addition to leading classical translational science (biomarkers, MoA, resistance, combinations, patient selection), the Head of Translational Oncology will be accountable for operationalizing bidirectional learning between translational/clinical data and AI/ML models—turning data into predictive insight and insight back into experimental and clinical strategy. This is a rare opportunity to build a next-generation translational function within an AI-native biotech.

Requirements

Ph.D., M.D., or equivalent advanced degree in cancer biology, molecular biology, pharmacology, computational biology, or a related discipline.
Typically 12–20+ years of relevant experience in biotech or pharma, with progressive leadership responsibility.
Demonstrated success advancing at least one oncology program into clinical development.
Deep expertise in translational science, including biomarker strategy, MoA, resistance, and combination biology.
Proven experience working with large, complex translational and/or clinical datasets, ideally incorporating bioinformatics and ML-based approaches.
Strong working knowledge of AI/ML concepts as applied to drug discovery and development; prior hands-on modeling experience is a plus but not required.
Track record of leading cross-functional teams, influencing without authority, and partnering effectively with computational and clinical colleagues.
Excellent scientific storytelling and communication skills, with the ability to frame evidence-based narratives for senior and executive audiences.