Head of Data Architecture and AI Solutions

Legend Biotech • Somerset, NJ

66d • $187,989 - $246,735 • Hybrid

About The Position

Legend Biotech is seeking Head of Data Architecture and AI Solutions as part of the IT team based in Somerset, NJ. The Head of Data Architecture & AI Solutions is a leadership position responsible for architecting, integrating, and scaling data and AI capabilities supporting our mission to advance cell and gene therapies. This highly visible role spans cross-functional teams-including R&D, Clinical Operations, Medical Affairs, Commercial, and Manufacturing-with a sharp focus on harmonizing enterprise data architecture and accelerating the application of AI/ML for real-world impact.

Requirements

• BS Degree
• Minimum 10+ years in data architecture, analytics platform design, or commercial data operations-ideally within biotech, pharma, or healthcare.
• Proven record designing and scaling cloud-native data platforms/data models in multifaceted settings (including early-stage or growth-phase companies).
• Deep understanding of oncology or cell therapy data (commercial, clinical, medical, or R&D).
• Demonstrated ability to operate independently and prioritize in a lean, entrepreneurial environment.
• Strategic and systems-oriented, with a passion for building scalable solutions and driving cross-enterprise alignment.
• Energetic self-starter-comfortable managing uncertainty, setting priorities, and influencing senior stakeholders.
• Highly collaborative; able to synthesize diverse viewpoints and translate ambiguous needs into concrete data/AI roadmaps.
• Pragmatic communicator-adept at concise documentation, presenting actionable concepts, and driving stakeholder engagement.
• Experience in oncology-driven biotech or pharma, especially pre-commercial/early commercial stage.
• Working familiarity with life sciences regulatory frameworks (GxP, privacy, retention, commercial).
• Experience driving requirements definition, collaborating with engineering, and integrating complex, heterogeneous data systems.
• Direct exposure to ML/AI in healthcare (predictive analytics, NLP, Gen AI, or decision support).
• Hands-on prototyping experience (Databricks, cloud notebooks, automation tools, etc.).
• Led or contributed to AI/ML/data platform initiatives within cross-functional/product teams.

Responsibilities

• Design, build, and continuously improve Legend Biotech's data lakehouse architecture to unlock analytics, reporting, and AI for enterprise users.
• Develop enterprise data models and semantic layers tailored for cell therapy workflows, enabling scalable self-service analytics and operational insights.
• Define integration strategy across enterprise applications (clinical, ERP, CRM, manufacturing, compliance) balancing traceability, integrity, and regulatory requirements.
• Identify and evaluate high-value opportunities for AI/ML in early development, clinical operations, supply chain, commercial analytics, and scientific knowledge management.
• Lead solution design for practical AI/ML pilots-coordinating in-house or external partners, ensuring alignment with Legend Biotech's digital and enterprise standards.
• Establish data readiness protocols for machine learning (annotation, pipeline integration, model monitoring/feedback, and secure deployment).
• Own enterprise systems integration, dataflow design, and harmonization.
• Implement master data management solutions supporting unified product, customer, clinical trial, and manufacturing data domains.
• Collaborate with platform engineering, infrastructure, and partner teams to maximize interoperability and leverage best-in-class/reusable assets.
• Lead metadata management, master data governance, and stewardship processes-ensuring alignment with GxP, privacy, and commercial compliance requirements.
• Set and monitor high standards for data quality, system validation, and audit-readiness in collaboration with business and technical stakeholders.
• Champion cross-functional data governance (ownership, access, lineage) in a highly regulated, complex data ecosystem.
• Serve as strategic advisor on data, analytics, and AI readiness-supporting business, R&D, and executive teams with actionable architectural guidance.
• Influence and align cross-functional partners toward shared goals and enterprise data priorities; champion 'digital-first' and Gen AI-enabled innovations.
• Establish and maintain strong relationships with Legend Biotech stakeholders.
• Recruit, onboard, and mentor a small, high-impact team as Legend Biotech scales.

Benefits

• Medical, dental, and vision insurance
• 401(k)-retirement plan with company match that vest fully on day one
• Equity and stock options available to employees in eligible roles
• Eight weeks of paid parental leave after just three months of employment
• Paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays
• Flexible spending and health savings accounts
• Life and AD&D insurance
• Short- and long-term disability coverage
• Legal assistance
• Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
• Commuter benefits
• Family planning and care resources
• Well-being initiatives
• Peer-to-peer recognition programs

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Bachelor's degree
• Number of Employees: 1,001-5,000 employees