Head of Clinical Sciences

Isomorphic Labs•Cambridge, MA

5d•Hybrid

About The Position

The experienced Head of Clinical Sciences will be the strategic architect of our clinical programs, leading studies from first in human (FIH) to proof-of-concept to registration. The role ensures clinical programs are aligned with corporate objectives, strategically designed, and deliver decision-ready data . Reporting to the Chief Medical Officer, this role will lead the protocol design and study delivery strategy. This role will work in close collaboration to establish, lead, and execute on the clinical development plan(s), and will have the opportunity to drive strategic decision-making to maximize the value of current and future clinical programs. Beyond the data, this role will champion a culture of scientific excellence, setting the bar for rigor and accountability as we scale our pipeline to reach patients faster.

Requirements

Education: Advanced degree (MD, PhD, PharmD).
Experience: 15+ years in the pharmaceutical/biotech industry, with a proven track record in small to mid-sized startup environments. Deep expertise in oncology or inflammation.
Track record: Proven success in leading programs from IND through late stage development. Experience leading successful regulatory filings.
Scientific Rigor: Strategic ability to interpret complex, ambiguous datasets to drive corporate strategy and mitigate development risks.
Leadership Effectiveness: Demonstrated success in a fast-paced matrixed environment. Strong interpersonal skills with the ability to influence without authority and resolve conflicts across global functions.

Nice To Haves

The Builder: Comfort in a fast-paced, evolving start up with experience building foundational capabilities from scratch.
The Diplomat: A master of cross-functional influence who can build consensus and navigate complex governance with high emotional intelligence.
The Innovator: Knowledge of industry trends and technologies to drive competitive advantage, leveraging automation or digital tools to simplify workflows and accelerate the path to patients.

Responsibilities

Lead the global clinical science strategy, endpoint selection, end-to-end protocol development, and associated amendment(s) across the full trial lifecycle, ensuring high level of quality and operational delivery.
Spearhead the end-to-end clinical data review process, synthesizing complex data to deliver evidence-based strategic recommendations to executive leadership.
Accountable for safety monitoring and risk management strategies, interpreting safety/efficacy data to guide critical decisions.
Author and review key clinical and regulatory documents.
Facilitate cross-functional collaboration to transition research stage assets to clinical development and integrate translational insights to influence broader program strategy.
Represent the organization in health authority interactions and lead the scientific rationale for regulatory responses.
Build and maintain strategic relationships with external partners (e.g., Key Opinion Leaders, Principal Investigators, and CROs) to validate program direction and support investor relations activities.
Define and implement scalable clinical science best practices, SOPs, and governance frameworks to ensure speed, consistency, and inspection readiness.
Define the unifying scientific messaging across internal and external stakeholders, supporting publication strategies and commercial positioning.
Collaborate with internal AI/ML teams to identify and implement technology-driven solutions to enhance scientific literature analysis, clinical data interpretation, and overall operational efficiency.
Requires some travel.