Head of Clinical Operations

Absci • Vancouver, WA

222d • $230,000 - $290,000

About The Position

Absci is a data-first AI drug creation company designing differentiated therapeutics using generative AI. Our Integrated Drug Creation platform powers cutting-edge de novo AI models and AI lead optimization models aimed at designing better biologics against difficult-to-drug targets. We seek an experienced Head of Clinical Operations to spearhead the planning and execution of Absci's clinical development programs. In this pivotal leadership role, you will combine strategic vision with hands-on operational excellence to guide our AI-designed antibody therapeutics from preclinical stages into and through clinical trials. In a largely outsourced model, you will lead all clinical trial planning and execution across a range of therapeutic areas (such as immunology and dermatology), ensuring programs are designed optimally and run efficiently to meet regulatory standards and company objectives.

Requirements

• Advanced degree in life sciences or related field (Ph.D., MD, PharmD, MSc or equivalent) preferred.
• Minimum 10+ years of progressive experience in clinical operations within the biotechnology or pharmaceutical industry.
• Experience managing global clinical trials across Phase 1-3 is required.
• Experience in immunology, inflammation, or oncology drug development is a plus.
• Deep knowledge of GCP, ICH guidelines, and FDA/EMA regulations governing clinical trials.
• Proven experience selecting, negotiating, and managing CROs and other clinical vendors.
• Excellent leadership skills with a history of leading high-performing teams.
• Excellent project management and organizational skills.
• Outstanding communication and interpersonal skills.
• A genuine interest in cutting-edge drug development technologies.

Nice To Haves

• Experience with biologics is a plus.
• Familiarity with IND/CTA submissions and the clinical contributions to NDA/BLA filings is desired.

Responsibilities

• Provide end-to-end leadership of Absci's clinical operations, from first-in-human studies through later-phase trials.
• Oversee the planning, initiation, and delivery of clinical trials across multiple therapeutic areas.
• Lead vendor selection, manage relationships with Contract Research Organizations (CROs), clinical sites, and other external vendors.
• Serve as a key liaison between Clinical Operations and other departments.
• Ensure all clinical activities adhere to Good Clinical Practice (GCP), ICH guidelines, and applicable FDA/EMA regulations.
• Proactively identify potential risks and operational challenges in study conduct.
• Continuously assess and optimize clinical operations processes, tools, and metrics.
• Oversee clinical operations, budgeting, and resource allocation for all studies.
• Represent Absci's Clinical Operations in interactions with external stakeholders.
• Oversee the collection of high-quality clinical data and ensure timely data review and cleaning.
• Drive patient-centric recruitment and retention strategies to meet enrollment targets.

Benefits

• Medical, dental, and vision insurance.
• Unlimited vacation.
• Parental leave.
• Breakfast and lunch for onsite employees.
• Employee assistance program.
• Voluntary life and disability insurance.
• Annual bonus potential.
• 401(k) with a generous company match.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree