Manifold Bio-posted 9 months ago
Full-time • Senior
Boston, MA
11-50 employees
Professional, Scientific, and Technical Services

Manifold Bio is seeking an experienced biotherapeutics expert to join our growing team pursuing our mission of multiplexed, in vivo drug discovery. This role will drive the protein therapeutic workflow at Manifold, from discovery through CMC. The ideal candidate will have extensive protein engineering experience across diverse formats and modalities and deep knowledge of protein production strategies to supply high throughput screening pipelines. You will focus on deploying cutting edge protein engineering technologies to reach best-in-class product profiles in a timely and cost-effective manner. Further, you will engage the rest of the R&D team to integrate your approaches with the unique protein multiplexing technology we've developed at Manifold. You will be a critical part of our transition from a discovery stage to a clinical stage company, bringing ample experience taking molecules through IND, particularly with regard to biologics manufacturing. Together, we'll continue to build a transformational company based on the vision of massively increasing the throughput of testing of protein therapeutic designs to fundamentally change the current paradigm of drug development.

  • Leading internal protein sciences and protein engineering teams
  • Own strategy for early stage de-risking and optimization of lead molecules
  • Own strategy for developability assessment
  • Work with internal and external team members to ensure cost-effective and timely drug manufacture
  • Build internal expertise on cutting-edge protein engineering techniques
  • Guide prioritization for internal protein generation efforts, balancing between screening and lead characterization
  • Build an R&D-to-development pipeline for lead candidates
  • Utilize state of the art techniques to drive the development of best-in-class therapeutic candidates
  • Stay up to speed on cutting edge research and industry standards for protein therapeutics
  • Experience taking multiple molecules through IND and into the clinic
  • Deep understanding of protein production techniques, including mammalian cell culture and purification/characterization approaches
  • Expertise in novel biotherapeutic modalities, across a range of formats
  • Extensive experience leading cross-functional teams
  • Experience with complex biologics (e.g. multispecifics)
  • Experience with drug development in neuroscience
  • Experience liaising with CDMOs through IND
  • Experience with generative AI models for protein design
  • We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.
© 2024 Teal Labs, Inc
Privacy PolicyTerms of Service