Global Head ADQC Gene Therapy

Genentech • Philadelphia, PA

7d

About The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech!
The Opportunity
The Global Head of Analytical Development and Quality Control (ADQC) is a key member of the Gene Therapy Technical R&D leadership team. This role is accountable for evolving science-driven, phase-appropriate, and risk-based analytical and quality control strategies for our global enterprise in vivo Gene Therapy portfolio.
Your remit spans the entire spectrum from candidate nomination through to commercialization of Gene Therapy related modalities. Your leadership will extend beyond our internal pipeline to actively shape the global Gene Therapy landscape. You will serve as a leading voice in the field, defining the next generation of industry standards and regulatory benchmarks for complex modalities.

Requirements

• Education and background: You hold an advanced degree (Master’s or PhD) in Chemistry, Biochemistry, Biology, or a relevant related discipline and possess a mastery of complex relevant analytical techniques (e.g., HPLC, Mass Spec, Genomics) alongside expert-level knowledge of CMC requirements and GMP standards.
• Experience: You bring 20+ years in research or the biotech industry, with progressively responsible experience in Gene Therapy or Biologics analytical development and at least 10 years in supervisory or lead roles.
• Domain knowledge: You possess deep technical expertise in viral vectors and nucleic acid formats. You understand the unique analytical and regulatory challenges associated with these platforms for in vivo Gene Therapy applications. You have a proven track record of steering diverse modalities—AAVs, plasmids, and RNAs— ideally through the entire lifecycle from early-stage development to successful commercial launch.
• Leadership: You are an inspiring authentic and visionary leader who builds, develops, and empowers high-performing, globally distributed teams. Deeply aligned with VACC (Visionary, Architect, Catalyst, Coach) and Roche Leadership principles, you guide teams through change and ambiguity with purpose, clarity, and a focus on growth in a fast-paced environment.

Responsibilities

• Enterprise Analytical Strategy: Define and evolve the global ADQC roadmap for the entire Roche Gene Therapy portfolio. Ensure a scalable, world-class organization capable of supporting diverse modalities, including AAVs and other Nucleic Acid based formats like plasmids or RNA formats from candidate nomination through commercialization.
• Organizational Design & Operating Model: Actively shape the global ADQC organizational structure and operating model to meet evolving business needs. You will ensure the function remains agile, appropriately resourced, and seamlessly integrated within the broader enterprise Gene Therapy and Technical R&D ecosystem.
• End-to-End Portfolio Oversight: Direct the development of science-driven, risk-based analytical strategies. Accountable for the seamless delivery of analytical methods, sample analysis, validation protocols and QC testing for process development and manufacturing across all global sites.
• Scientific advancement & Innovation: Lead the evolution and global implementation of state-of-the-art analytical capabilities. Champion the development of novel methods for viral vectors and nucleic acids, ensuring the organization remains at the forefront of scientific and regulatory excellence.
• Global Governance & Partnership: Serve as the authoritative voice for ADQC within integrated project teams and global governance and advisory boards, partnering with Research, Regulatory, QA, MSAT, and Manufacturing to ensure CMC alignment. Actively influence the gene therapy landscape by collaborating with external stakeholders and Health Authorities to define and implement next-generation industry benchmarks.

Benefits

• Relocation benefits are available for this job posting.
• The expected salary range for this position based on the primary location of Philadelphia, PA is $227,400 - $422,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive
• Education Level: Ph.D. or professional degree