Exp Sci Biotherapeutics R&D

Johnson & Johnson Innovative Medicine • Spring House, PA

3d • Onsite

About The Position

About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/. An internal pre-identified candidate for consideration has been identified. However, all applications will be considered. We are searching for the best talent for Experienced Scientist, located in Spring House, PA. Purpose: As part of this role, you will be responsible for developing assays to understand novel biotherapeutic expression systems. Your experience in LC-MS, ELISA, and protein analysis techniques will be valuable in optimizing our platform and facilitating the production of high-quality biotherapeutics. Join our pioneering mass spectrometry laboratory and gain access to the latest instruments, robotic workbenches for automated sample handling, and powerful bioinformatic software and cloud computing resources. Working in a dynamic and interdisciplinary setting, you will collaborate with multi-functional teams, including those specializing in cell line development and cell culture process development. In this role, you will offer expert guidance on extensive Mass Spec characterization of biotherapeutics and explore various aspects of cellular and protein expression within cells. Through your valuable contributions, you will actively contribute to the advancement of our biopharmaceutical pipeline. Joining our team as a biotherapeutic R&D Experienced Scientist specializing in cell line development offers a unique and exciting opportunity to contribute to the development of innovative biopharmaceutical products. If you are passionate about protein characterization, automation, and mass spectrometry, and thrive in an exciting and collaborative scientific environment, we encourage you to apply and become part of our team.

Requirements

• Master’s degree in life sciences with 1+ years of experience OR bachelor's degree in life sciences with 3+ years experience.
• 1-3 years of experience in automation, peptide quantitation, sample preparation, mass spectrometry-based analysis, and interpretation.
• Experience developing automated sample preparation workflows
• In-depth experience operating mass spectrometers from all vendors and optimizing instrument parameters and data analysis.
• Proven track record of working independently and collaboratively in a multidisciplinary team environment.
• Excellent problem-solving skills and attention to detail.
• Strong written and oral communication skills, with the ability to effectively summarize and communicate in-depth MS results to multi-disciplinary teams.

Nice To Haves

• Experience in biotherapeutic mass spectrometry workflows and data analysis.
• Experience working with Echo MS
• Proven experience in mass spectrometry protein characterization.
• Experience with data processing via Protein Metrics.
• Prior experience in the biopharmaceutical industry or related fields.
• Solid understanding of mass spectrometry and MS sample preparation.
• This role is based in Spring House, PA and may require 5% travel.

Responsibilities

• Develop and implement mass spectrometry assays to optimize protein expression levels, protein quality, and quantitation of biotherapeutics. Ensure accuracy and success of MS experiments through expertise in sample preparation.
• Use advanced liquid chromatography-mass spectrometry (LC-MS/MS) technologies for protein identification and characterization.
• Employ automation to enable high throughput mass spectrometry characterization.
• Analyze antibodies using peptide mapping, intact mass analysis, native mass spectrometry, and acoustic ejection mass spectrometry.
• Collaborate with other functions and teams to design experiments that address critical questions.
• Troubleshoot technical issues and propose innovative solutions to enhance analytical capabilities.
• Prepare and present scientific findings and recommendations to internal customers, project teams, and senior management.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level