Executive Director, Early Differentiation & Pipeline, Global Medical Neuroscience

Bristol Myers Squibb • Princeton, NJ

6d • Hybrid

About The Position

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. The Executive Director, Early Differentiation & Pipeline (EDAP), Global Medical Neuroscience will lead the early‑stage medical strategy to differentiate pipeline assets and accelerate high‑value programs from discovery through key governance milestones. This role shapes integrated evidence strategies (clinical and real‑world), defines target product profiles (TPPs), advances biomarker/diagnostic and personalized care approaches, and drives cross‑functional portfolio decisions that maximize launch readiness, patient access, and long-term lifecycle value across Neuroscience, with strategic alignment to Neuroscience portfolio. The leader will steward external scientific engagement, research collaborations, and scientific communications. while leading and coaching a high‑performing Early Asset Medical team. The Executive Director, Global Medical Neuroscience EDAP, will lead a team of Medical Strategy leads and Medical Product Leads (MPLs) and reports directly to the SVP, Global Head of Medical Affairs, Neuroscience will be key part of the Medical Neuroscience leadership team. This role will focus specifically on early pipeline assets in Phase 1 and Phase 2 signal-seeking development, maintaining dynamic prioritization of assets in partnership with discovery and early development teams to ensure efforts are invested in the most promising assets.

Requirements

• Medical Degree (MD or equivalent), PhD, or PharmD required
• 10+ years of diverse experience in development, clinical, or medical affairs roles.
• ≥5 years Neuroscience-specific experience (neurodegeneration, neuropsychiatry, neuroinflammation, etc.).
• Previous commercial launch experience, preferably at local country level.
• Strong understanding of the biopharma drug development and commercialization process.
• General knowledge of pharmaceutical operations, i.e., advocacy, medical affairs, clinical development, regulatory.
• Minimum 10 years of leadership experience in the pharmaceutical/life sciences industry and in academic, neurological clinical service and neuroscience research with considerable experience with stakeholders and organizational engagement or partnerships (public and/or private) within neurology and neuroscience.

Nice To Haves

• Experience in early-phase clinical development or translational science preferred.
• Prior experience in either Medical or Development preferred.
• Excellent track record in impactful scientific neuroscience and Alzheimer’s disease research output (publications) preferred.
• Experience in business development or due diligence preferred.

Responsibilities

• Early Pipeline Differentiation & Evidence Strategy Collaborate with Discovery, Early Development, Translational Research, and Early Transition Assets on biomarker/diagnostic strategies and personalized care approaches, with particular emphasis on neuroimaging technologies, digital endpoints, and companion diagnostics (CDx) as well as their potential clinical applicability/utility.
• Understand the role of biomarkers, neuroimaging, digital endpoints, and diagnostic platforms in determining treatments across neurological diseases and integrate this understanding into early program strategic approaches.
• Lead creation of early Integrated Evidence Plans (IEPs) that differentiate clinical endpoints and real‑world outcomes.
• Shape IEPs and CCF plans beyond regulatory minimums to address unmet needs.
• Provide key input to define optimal Target Product Profiles (TPPs).
• Inform and accelerate governance decisions on priority programs to ensure maximum transformational clinical value is captured via Clinical Development Plans (CDP) and Integrated Evidence Plans (IEP).
• Represent medical perspective in business development and licensing activities.
• Make recommendations to research and clinical development teams based on external landscape and insights from scientific partnerships and external experts.
• Ensure deep local and stakeholder insights inform pipeline shaping.
• Portfolio Shaping, Governance & Prioritization Drive cross‑functional shaping across Neuroscience portfolios.
• Deliver early‑program strategic assessments to prioritize transformational assets.
• Establish cross-asset medical strategies maximizing lifecycle value and patient access.
• Maintain an ongoing dynamic prioritization of assets in partnership with discovery and early development teams to ensure efforts are invested in the most promising asset.
• Ensure global alignment of medical strategic priorities across the Medical Matrix.
• Evidence Generation, Access & Operations.
• Partner with Medical Evidence Generation (MEG), Global Drug Development (GDD), Global Development Operations (GDO), Health Economics and Outcomes (HEOR), and Disease Area Heads (DAH) on portfolio‑level evidence strategies.
• Align with Markets and Disease Area Leads on evidence generation priorities.
• Collaborate with Market Access/HEOR on HTA‑relevant strategies and data gaps.
• Integrate GDO and Regional Clinical Operations (RCO) to ensure feasibility and operational excellence.
• Identify and execute opportunities for medical affairs-enabled signal generation for priority assets, leveraging internal organization as well as external trusted centers of excellence.
• External Engagement, Collaborations & Communications Build early scientific partnerships, councils and research collaborations at top centers of excellence for neuroscience research.
• Identify and enable pre‑clinical, translational, clinical, Real-World Evidence (RWE), and digital health collaborations.
• Drive early medical expert and scientific engagement globally.
• Ensure strong Scientific Communications plans across therapeutic areas, including comprehensive publication planning integrated into priority asset plans.
• Oversee early pipeline strategy for medical congresses and ensure pipeline scientific communications are tied to strategy for all congresses.
• Partner on omnichannel, Artificial Intelligence / Machine Learning (AI/ML), and analytics‑driven solutions.
• Leverage novel approaches to integrating patient journey insights into early compound differentiation strategies.
• Support HTA and reimbursement‑related scientific engagements.
• Oversee the Asset Integrated Medical Teams (AIMs) to ensure asset strategies reflect global needs.
• Early Pipeline Medical Leadership Lead a team of senior medical affairs professionals focused on early Neuroscience assets, ensuring optimal differentiation, clinical value, and strategic fit to clinic.
• Shape the early Neuroscience portfolio narrative and communicate strategy clearly to internal and external stakeholders.
• Leverage a strong understanding of the medical landscape, neuroscience disease biology, and medical affairs strategies for early-phase assets.
• Bring a patient lens and perspective to early development and ensure plans are reviewed with external stakeholders.
• Partner with cross-functional teams to create a clear and compelling scientific story for portfolio and individual compounds.
• Provide leadership in relation to biomarkers, neuroimaging, digital endpoints, and companion diagnostics as well as potential clinical applicability/utility.
• Enhance the differentiated clinical value and leadership of our early portfolio by shaping the design and implementation of innovative biomarker solutions, neuroimaging technologies, digital health tools, diagnostic platforms, software and big data solutions, and strategic collaborations.
• Compliance/Standards Adherence to job specific SOP and work instructions, completion of assigned SOPs and training within designated timeframe and adheres to job-specific SOPs.
• Conducts business in accordance with BMS Values.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
• Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree