Executive Director, Clinical Operations Program Management (CVRM)

AstraZeneca • Boston, MA

1d • Hybrid

About The Position

We are seeking a motivated, collaborative, data‑driven enterprise leader to shape and deliver the Cardiovascular, Renal & Metabolic (CVRM) clinical operations portfolio. As Executive Director, Clinical Operations Program Management, you will lead Senior/Global Program Directors across early and late development, translate CVRM strategy into clear operational objectives, and drive disciplined, insight‑led decision‑making to deliver trials to time, quality, and cost.

Requirements

• Education: Bachelor’s/Master’s in a related discipline; advanced degree preferred.
• Experience: extensive global drug development leadership across early and late phase; significant program management with complex projects (resourcing, financials, business cases).
• Expertise: strong understanding of complex study design, TPPs, CDPs, competitive dynamics, pricing, market access, and global regulatory environments.
• Skills: strategic influencing, clear and organized thinking, financial evaluation of assets/brands, business planning, high‑impact communication and presentation.
• Leadership: proven ability to lead, mentor, and develop diverse high‑performing teams; collaborate across disciplines; plan, prioritize, and deliver.
• Digital: comfortable utilizing AI for ethical, accurate data analyses.
• Travel: willingness for domestic and international travel.

Nice To Haves

• Process transformation: driving efficiency and implementing new ways of working.
• Regulatory: submission experience; insights from Japan and China delivery.
• Change leadership: leading teams through change; clinical environment insight.

Responsibilities

• Functional leadership: line‑manage and develop Program Management Senior Directors; recruit, resource plan, and build capabilities.
• Coaching and culture: mentor teams, champion new ways of working, foster collaboration, accountability, and continuous improvement.
• Strategy translation: convert CVRM strategy into forward‑looking clinical operations objectives across early and late programs.
• Operational excellence: ensure robust strategic and operational planning; lead operational planning reviews; secure successful asset transitions from CDID to Phase III.
• Performance: deliver portfolio to time, quality, and cost; proactively identify trends, risks, and opportunities using internal and external data.
• Enterprise impact: represent Clinical Operations at governance and decision bodies (e.g., DRC, PRC); serve on Steering Committees and cross‑functional initiatives.
• Best practices: drive clarity and consistency across strategic processes; establish standards for trial delivery; share lessons learned across TAs.
• Insight‑driven recommendations: conduct rigorous analyses to inform resourcing and delivery optimization; provide clear, actionable guidance to leadership.
• AI enablement: leverage AI and advanced analytics to enhance efficiency of clinical operations resources and decision quality.
• Partnerships: engage AROs, CROs, labs, KEEs, and development partners; represent Clinical Operations at congresses, investigator meetings, and with health authorities.

Benefits

• Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans.
• Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive
• Number of Employees: 5,001-10,000 employees