Engineer II, Upstream Viral Vector Product Development

AstraZeneca • Cambridge, MA

29d • Onsite

About The Position

The Engineer II in the Upstream Process Development team will play a key role in the development of adeno-associated virus (AAV) production processes for gene therapy applications. This position involves working collaboratively with a multidisciplinary team to design, optimize, scale up, and tech transfer upstream processes involved in the production of viral vectors.

Requirements

• BS or MS degree in Biomedical Engineering, Chemical Engineering, Biotechnology, or a related field
• Minimum of 2+ years of relevant experience in the biotech industry
• Hands-on experience with mammalian cell culture and aseptic technique
• High level of proficiency in MS Office software

Nice To Haves

• Experience with bioreactor set up and operation.
• Experience with AAV or other viral vectors and transient transfection
• Experience with statistical analysis and design of experiment (DOE)

Responsibilities

• Support Upstream Development including the design and execution of laboratory experiments to develop and optimize upstream processes for AAV production, including cell culture, transfection, production, and harvest/lysis.
• Troubleshoot process-related challenges and implement corrective actions to optimize production yields and maintain product quality.
• Perform routine Upstream laboratory tasks such as shake flask and bioreactor sampling and cell maintenance.
• Manage and maintain lab equipment and supplies, ensuring a safe and efficient work environment. This includes regular lab cleaning, equipment maintenance, and supply procurement.
• Analyze and interpret experimental data, utilizing statistical tools to drive scientific decision-making and process improvements.
• Collaborate with cross-functional teams including Downstream, Process Analytics, and Research.
• Support the transfer of upstream processes to cGMP manufacturing.
• Document experiments and results clearly and accurately in production files and electronic laboratory notebooks; Summarize and present results to the broader team.
• Support the drafting of process development reports, process descriptions, and tech transfer documents.

Benefits

• qualified retirement programs
• paid time off (i.e., vacation, holiday, and leaves)
• health, dental, and vision coverage in accordance with the terms of the applicable plans
• short-term incentive bonuses
• equity-based awards for salaried roles and commissions for sales roles

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees