As part of the Thermo Fisher Scientific team, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every day, enabling our customers to make the world healthier, cleaner, and safer. We provide our global teams with the resources needed to achieve individual career goals while helping to take science a step further by developing solutions to some of the world’s toughest challenges, such as protecting the environment, ensuring food safety, and finding cures for cancer. Location South San Francisco, CA. Relocation assistance is NOT provided. Must be legally authorized to work in the United States without sponsorship. Must be able to pass a comprehensive background check, which includes a drug screen. Discover Impactful Work: Join our Systems Design Engineering team to develop next-generation sequencing instruments, applications, and reagents for the Clinical Sequencing Division. As part of multi-functional project teams, you'll advance automated workflows—including DNA extraction, library preparation, templating, and sequencing—from feasibility through on-market customer support. A Day in the Life: System Evaluation & Integration: Evaluate proposed NGS systems and workflows, integrate and characterize new technologies, and establish feasibility through rigorous experimentation. Workflow Automation & Optimization: Translate complex molecular biology and chemical protocols from benchtop to automated platforms. Optimize hardware-workflow interactions for performance, reliability, and robustness. Experimentation & Troubleshooting: Design hypothesis-driven experiments to characterize system performance and identify failure modes. Apply first-principles thinking to diagnose and resolve complex issues spanning molecular biology, chemistry, hardware, consumables, and software. Cross-Functional Collaboration: Partner with assay development scientists and hardware engineers, providing data-driven feedback to guide co-development of reagents, consumables, and instrument hardware. Platform Support & Feature Development: Provide expert-level technical support for on-market instruments and Field Support teams. Develop automated hardware diagnostics and new features that integrate hardware, consumables, and software into seamless automated solutions.