Engineer I, Upstream Development for Protein Development and Manufacturing (Contract)
About The Position
Vaxcyte is seeking a talented and experienced Engineer I/II, to join the Upstream Process Development group within the Protein Development and CMC team. This is an exciting opportunity to join an outstanding team pursuing bacterial fermentation development at Vaxcyte. The successful candidate will have the following skills and qualities: Hands-on experience operating and maintaining bioreactors, including Ambr® 250, at laboratory scale. Experience with pilot scale fermentation and recovery equipment is a plus. Skillful in analyzing and presenting data for process improvements, troubleshooting, and optimization. An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals. Strong organizational and planning skills.
Requirements
- BS in Chemical Engineering or a related discipline with 8+ years, MS with 4+ years, or PhD with 0-2 years of relevant Pharma/Biotech industry experience.
- Hands-on experience with fermentation and/or primary recovery unit operations.
- Good understanding in fundamentals of bioreactor design, operation and controls.
- Strong knowledge of aseptic techniques
- Understanding of fermentation scale up and development of scale down models
- Familiarity with DoE (Design of Experiments) principles and software.
- Familiarity with regulatory requirements of biotherapeutics. Late-stage process characterization experience is a plus.
Nice To Haves
- Experience with pilot scale fermentation and recovery equipment is a plus.
- Mechanical and technical knowledge of primary recovery unit operations such as homogenization, centrifugation, and depth filtration, is a plus
- Familiarity with regulatory requirements of biotherapeutics. Late-stage process characterization experience is a plus.
Responsibilities
- Lead operational activities related to bioreactor set-up, monitoring, harvest, and maintenance.
- Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls.
- Provide engineering support for design, implementation, and qualification of scale-down models.
- Author SOPs (standard operating procedure), process flow diagrams and batch records.
- Analyze and present fermentation data at internal project meetings. Participate in upstream database management and documentation in electronic notebooks.
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What This Job Offers
Career Level
Entry Level
Number of Employees
101-250 employees
