E11 Bio - Scientist, In vivo circuit mapping

Convergent Research • Alameda, CA

318d • $83,000 - $144,000

About The Position

E11 Bio is on a mission to advance connectomics towards whole brain scale for humans and other mammals. We are a collaborative and interdisciplinary team of scientists and engineers engaged in a neuroscience moonshot project to develop a radical technology platform for scalable mammalian brain mapping. E11 Bio is a non-profit Convergent Research focused research organization located in Alameda, California, pursuing blue-skies neuroscience research yet operating like a nimble, tight-knit start-up. E11 is seeking a circuit mapping scientist to help engineer viral and cellular labels for a moonshot effort making whole-brain connectomics feasible in humans and mice to revolutionize neuroscience and medicine. Your primary mission as a Scientist, circuit mapping is to design, execute on, and optimize our in vivo barcode delivery, the heart of E11's technology stack.

Requirements

• Experience with mouse genetics and/or in vivo viral labeling of neural circuits.
• Basic Python and command line usage skills.
• Experience with biological barcoding systems (e.g. MAPseq; rabies-based; Brainbow; in vivo pooled screens; lineage tracing).
• Experience collaborating on time-sensitive projects with large numbers of experimental conditions.

Nice To Haves

• Experience collaborating in a team structure across multiple projects.

Responsibilities

• Shadow and work with the lead barcoding scientist on ongoing experiments in the first month.
• Launch first labeling experiments with the help of the in vivo surgeon.
• Identify parts of the process in need of an overhaul and become familiar with E11’s cross-functional teams.
• Image, analyze, and communicate out the first set of barcoding results by the second month.
• Own at least 2 in vivo experiments from start to finish and maintain all molecular & viral reagents required.
• Initiate a plan to expand the ability to label & read out barcoded neural circuits in collaboration with the lead barcoding scientist.
• Fully own coordination of circuit labeling at E11 and hand-offs to other team members by the third month.
• Streamline experiment execution and proactively seek ways to improve the process.
• Drive the project for neural circuit labeling forward, executing on design, in vivo delivery, readout, and analysis.

Benefits

• Excellent medical, dental, and vision insurance through a PPO plan; parental leave.
• Generous time off + paid holidays.
• Wellness allowance for fitness and wellness activities.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level