Downstream Scientist

ZP Group • Frederick, MD

68d • $80,000 - $120,000

About The Position

Piper Companies is seeking a Downstream Scientist to support high-quality biologics manufacturing for both clinical and commercial use. This position focuses on downstream process development, scale-up, and technology transfer, with hands-on responsibilities in purification operations and troubleshooting. The ideal candidate will collaborate with cross-functional teams to ensure robust and efficient purification processes for large molecule therapeutics.

Requirements

• Bachelor's degree in a relevant scientific discipline.
• 3-7 years of experience in downstream process development or technology transfer in biologics manufacturing.
• Strong background in biologics manufacturing within a cGMP pharmaceutical or CDMO environment.
• Expertise in unit operations including chromatography, viral inactivation, filtration, and UF/DF.
• Familiarity with upstream operations and mammalian cell culture.
• Experience with CMC activities related to downstream processes.
• Proficient in troubleshooting purification processes and implementing process improvements.
• Skilled in MVDA tools and data-driven process analysis.
• Strong documentation skills with adherence to GDP and GMP standards.
• Excellent problem-solving, communication, and collaboration abilities.

Responsibilities

• Execute and optimize downstream purification processes including chromatography (affinity, ion exchange), viral inactivation, filtration, and ultrafiltration/diafiltration (UF/DF).
• Support technology transfer of downstream processes to commercial manufacturing.
• Monitor process performance and troubleshoot purification challenges.
• Conduct small-scale purification studies for process characterization, scale-down model qualification, and process optimization.
• Analyze and interpret experimental data using multivariate data analysis (MVDA) tools.
• Collaborate with upstream, analytical, and manufacturing teams to resolve process issues and implement improvements.
• Document experimental procedures and results in compliance with Good Documentation Practices (GDP).
• Author and review technical reports and contribute to regulatory documentation.
• Present findings and technical recommendations in internal and external meetings.

Benefits

• Salary Range: $80,000.00 - $120,000.00/year, based on experience and certifications.
• Comprehensive Benefits: CIGNA Medical, Dental, Vision; 401k through ADP, 10 PTO days/5 Holidays.
• High growth potential in a very exciting and professionally nurturing environment!

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Industry: Professional, Scientific, and Technical Services
• Education Level: Bachelor's degree
• Number of Employees: 251-500 employees