Distinguished Scientist, Discovery Chemistry

Roche•South San Francisco, CA

68d

About The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech, a member of the Roche Group. The Opportunity We have an exciting opportunity for an experienced scientific leader and medicinal chemist to join our Small Molecule Drug Discovery Chemistry Department at Genentech in South San Francisco, CA. The successful candidate will be responsible for leading drug discovery project teams through various stages of therapeutic target identification, druggability, preferred mode-of-action assessment, hit-finding enablement, hit-to-lead, and lead optimization in a multi-disciplinary, team-based culture. They will have particularly deep expertise in the early stages of drug discovery projects and would be working closely with therapeutic area leaders to evaluate potential targets. The position will entail responsibilities for influencing drug discovery practices and interacting directly with various functions such as Biochemical and Cellular Pharmacology, Drug Metabolism and Pharmacokinetics, Pharmaceutical Sciences, Safety Sciences, and Structural Biology. Who We Are Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours. To apply today, click on the "Apply for this job" button.

Requirements

Ph.D. with 15+ years of medicinal chemistry experience in industry in the design and synthesis of analogs for molecular targets by applying state-of-the-art structure-driven and property-based design principles with deep experience in establishing and implementing successful partnerships with contract research organizations (CROs).
Demonstrate a strong record of accomplishments as noted by significant and creative contributions to the success of small-molecule projects.
Convey strong verbal and written communication skills and an ability to work collaboratively in teams.

Nice To Haves

Particular enthusiasm for mentoring colleagues across a wide range of experiences and disciplines is desired.

Responsibilities

Leading drug discovery project teams through various stages of therapeutic target identification, druggability, preferred mode-of-action assessment, hit-finding enablement, hit-to-lead, and lead optimization in a multi-disciplinary, team-based culture.
Working closely with therapeutic area leaders to evaluate potential targets.
Influencing drug discovery practices.
Interacting directly with various functions such as Biochemical and Cellular Pharmacology, Drug Metabolism and Pharmacokinetics, Pharmaceutical Sciences, Safety Sciences, and Structural Biology.
Lead, mentor, and provide career development for department staff and influence medicinal chemistry teams.