Discovery Scientist

Arcellx • Rockville, MD

257d

About The Position

Arcellx is a clinical-stage biotech company focused on the development of novel cell-based cancer therapies. The company is seeking Scientists (levels Associate Scientist to Senior Scientist, depending on skill and experience) to collaborate in the innovation, discovery, and development of protein and cell-based therapies. The successful candidate will work closely with a dedicated team of protein engineers and other departmental groups to identify, produce, characterize, and optimize recombinant proteins for therapeutic use in oncology. The role requires expertise in protein engineering and a strong track record of innovation and creativity.

Requirements

• PhD in the life sciences (e.g. Biochemistry, Chemistry, Chemical Engineering, Biology, immuno-oncology), with minimum of 2 years post-degree experience in protein engineering.
• Extensive experience in the design, construction, expression, characterization and optimization of recombinant proteins.
• Experience with biopharmaceutical product design and lead optimization is ideal.
• Experience in the design and execution of selection and screening strategies, utilizing phage display (or a related display method).
• Proficiency with high throughput screening, sequencing and characterization of bacterial clones.
• Experience with optimizing expression yield and quality. Experience with multiple protein expression systems (e.g. bacterial, yeast or mammalian systems) is preferred.
• Experience utilizing and developing appropriate methods for assessment of protein-protein interactions (e.g. ELISA, Octet BLI, Biacore SPR, MSD).
• Experience with sequence analysis software (e.g. SnapGene, Sequencher, Lasergene, BLAST, etc.), including construct and primer design and sequence confirmation.
• Programming experience with Python and/or R (R Studio) is ideal.
• Experience in oncology, immunology, and translational research is ideal.

Responsibilities

• Collaborate with other scientists to design, generate and characterize recombinant proteins, including biopharmaceutical products.
• Develop and execute selection and screening strategies using phage, yeast and mammalian display.
• Evaluate existing and emerging technologies, techniques and tools to enhance products and streamline discovery workflows.
• Independently plan, design, execute, record and analyze experiments.
• Summarize and present data in internal meetings and discussions.
• Write and review technical protocols and reports. Coauthor scientific abstracts, manuscripts and presentations.
• Manage and drive the advancement of internal projects, products or technology initiatives.

What This Job Offers

• Career Level: Entry Level
• Industry: Professional, Scientific, and Technical Services
• Education Level: Ph.D. or professional degree
• Number of Employees: 101-250 employees