Director, Supply Chain

ORIC Pharmaceuticals•San Diego, CA

4d•$200,000 - $220,000

About The Position

ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s clinical stage product candidates include (1) ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) ORIC-114, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. Beyond these two product candidates, ORIC® is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. The Director of Clinical Supply Chain is responsible for leading the strategy, planning, and execution of global clinical trial supply activities across all phases of development. This role ensures uninterrupted supply of investigational medicinal product (IMP), comparator drugs, and ancillary materials to support clinical trials while maintaining full compliance with global regulatory requirements. The Director oversees end-to-end clinical supply operations including forecasting, manufacturing coordination, packaging, labeling, depot distribution, inventory management, and drug accountability. This position also leads vendor governance and works cross-functionally with Clinical Operations, CMC, Quality, Regulatory Affairs, and Finance to ensure clinical programs are supported by a robust and reliable supply chain. The successful candidate will combine strategic leadership with hands-on execution in a fast-paced biotech environment.

Requirements

Minimum 15 years of supply chain experience in the pharmaceutical industry preferred.
Bachelor's or master’s degree with 12+ years of relevant global supply chain management experience in the pharmaceutical industry a plus.
Deep experience in global late phase clinical supply is preferred.
Strong understanding of regulatory and technical influences and ability to assess business and financial implications of decisions
In-depth technical operations and quality knowledge as well as applied expertise in GMP and GDP regulated facilities
Experience managing external suppliers such as Clinical Depots, 3PL and Logistics providers

Nice To Haves

Certified Supply Chain Professional (CSCP) certification a plus.

Responsibilities

Clinical Supply Strategy & Planning
Develop and execute global clinical supply strategies across Phase 1–Phase 3 clinical development programs.
Translate clinical protocols and enrollment assumptions into supply forecasts and operational supply plans.
Design supply strategies for complex trials including multi-arm studies, global trials, and physician-choice arms.
Develop integrated supply plans covering manufacturing, packaging, labeling, distribution, and resupply.
Perform supply risk assessments and scenario planning to mitigate supply interruptions.
Lead demand forecasting and supply modeling using appropriate planning tools and simulation approaches.
Provide clinical supply input during protocol development and study feasibility discussions.
Clinical Trial Materials Management
Oversee the end-to-end lifecycle of clinical trial materials from production through distribution and reconciliation.
Manage investigational product supply, including lot tracking, expiry management, and retest date monitoring.
Ensure timely packaging, labeling, and release of clinical trial materials.
Track clinical inventory across manufacturing sites, depots, and clinical sites.
Ensure proper documentation and traceability of all clinical trial materials.
Oversee drug returns, destruction, and final study reconciliation activities.
Vendor & External Partner Management
Serve as the business owner for key clinical supply vendors including:
Clinical packaging and labeling providers
Clinical depots and 3PL providers
Comparator sourcing vendors
RTSM / IRT system providers
Clinical manufacturing and distribution partners
Lead vendor selection, contracting, and onboarding processes.
Manage Master Service Agreements (MSAs), Statements of Work (SOWs), and change orders in collaboration with Legal and Finance.
Establish vendor performance metrics and conduct regular business reviews.
Ensure vendors operate in compliance with GxP requirements and study timelines.
Clinical Depot & Global Distribution Management
Lead selection and oversight of global clinical depots and distribution partners.
Develop depot strategies to ensure efficient global supply distribution.
Ensure appropriate temperature-controlled logistics and chain-of-custody controls.
Oversee import/export processes and country-specific regulatory requirements for IMP distribution.
Manage depot inventory levels to ensure site readiness and prevent supply shortages.
Comparator & Ancillary Supply Strategy
Develop strategies for sourcing comparator drugs required for clinical trials.
Manage procurement of commercially available reference products when manufacturer supply agreements are unavailable.
Oversee procurement and management of ancillary supplies required for clinical trials.
Ensure full regulatory compliance, traceability, and documentation of comparator and ancillary products.
IRT / Clinical Supply Systems
Partner with Clinical Operations to design and implement IRT/RTSM systems supporting randomization and supply management.
Define resupply algorithms including site buffer levels, demand assumptions, and resupply triggers.
Monitor ongoing supply performance using system-generated data and analytics.
Ensure alignment between randomization strategies and supply distribution.
Inventory Management & Drug Accountability
Establish processes for clinical inventory tracking across manufacturing, depots, and sites.
Ensure accurate investigational product accountability.
Monitor inventory health including expiry management and wastage mitigation.
Oversee reconciliation of clinical supplies at study closeout.
Regulatory Compliance & Quality Oversight
Ensure clinical supply activities comply with applicable global regulations including GCP, GMP, and GDP.
Support regulatory submissions requiring clinical supply documentation.
Partner with Quality to support inspections, audits, deviation investigations, and CAPA management.
Maintain SOPs and documentation governing clinical supply operations.
Cross-Functional Leadership
Serve as the clinical supply representative on global clinical program teams.
Collaborate with:
Clinical Operations
CMC / Manufacturing
Quality Assurance
Regulatory Affairs
Finance and Procurement
Provide leadership and supply expertise to support clinical development strategy.
Budget & Financial Management
Develop and manage clinical supply budgets including packaging, depot operations, comparator procurement, and logistics.
Track supply chain spending against study budgets and forecasts.
Provide leadership with supply cost projections and scenario analyses to support decision making.