Director, Statistical Programming

Maze Therapeutics • South San Francisco, CA

8h • Hybrid

About The Position

The Opportunity Maze is looking for a Director of Statistical Progr ammi ng , who will help shap e the data foundation of our clinical development programs . In thi s role y ou’ll collaborate closely with colleagues across Biostatistics, Clinical Data Management, Clinical Operations, and Regulatory Affairs, and oversee external vendors to keep our studies rigorous, high-quality, and ready for regulatory review . You’ll report to the Vice President of Biometrics and lead the stra tegy and day-to-day execution of statistical programmi ng across multiple clinical studies . You r leadership will ensure we deliver reliable, efficient , and regulatory-c ompliant programming outputs that drive smarter decisions and ad vance our therapeutic programs.

Requirements

• An advanced degree in Statistics, Computer Science, Mathematics, or related discipline
• Master’s degree with 10+ years of experience, or Ph.D. with 8+ years of experience
• A track record of leading statistical programming efforts across multiple clinical studies or regulatory submissions.
• Strong decision-making skills and the a bility to guide teams through ambiguity while influencing across project teams.
• A collaborative leadership style that emphasizes mentorship, knowledge sharing, and developing others.
• Deep technical expertise in statistical programming for clinical research, with familiarity in CDISC standards, submission ‑ ready deliverables, and modern programming best practices.

Responsibilities

• Define and implement statistical programming strategy , standards, and best practices across development programs
• Lead the design, development, validation , and maintenance of SAS macros, scripts, and applications supporting clinical data analysis, reporting, and regulatory deliverables (e.g., SDTM, ADaM datasets, TLFs)
• Ensure programming infrastructure is robust , scalable, and compliant with regulatory standards (e.g., FDA 21 CFR Part 11, GxP ), and supports reproducibility and audit readiness
• Drive automation and standardization of programming workflows to improve efficiency and consistency across studies
• Partner closely with Biostatistics, Clinical Data Management, Regulatory Affairs , and IT to define programming requirements, align on analysis/reporting deliverables, and ensure data integrity
• Represent the statistical programming function in cross-functional meetings and strategic initiatives
• Manage CROs and external programming vendors , including scope, timelines, quality, and budget oversight
• Support outsourcing strategy and vendor selection
• Builds communication channels across Maze for sharing information.
• Influences Senior Management decisions through persuasive arguments.
• Respectfully addresses differing opinions leading to support of decisions.
• Champions partnerships and connections across Maze.
• Proactively addresses issues that could result in breakdown of team relationships.
• Spotlights team and individual contributions in public forums.
• Addresses gaps and leverages strengths to get best results.
• Maintains a steadying presence and clarifies priorities during change.
• Anticipates and removes barriers that put functional/corporate goals at risk.
• Remove barriers to staff development and empowers them to make their own decisions.
• Stays current on industry trends and keeps direct-reports prepared and responsive.

Benefits

• Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree