Director/Sr. Director, Clinical Pharmacology

BridgeBio Pharma•Palo Alto, CA

7h•Hybrid

About The Position

Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. What You'll Do BridgeBio is seeking an experienced Director/Sr. Director of Clinical Pharmacology to help grow our biologics pipeline, with a primary focus on nonclinical antibody therapeutics. This candidate will serve as the clinical pharmacology leader: shaping nonclinical and clinical strategy, guiding quantitative approaches, and ensuring high-quality execution across nonclinical and clinical development. This is a high-impact leadership role in a fast-moving biotech environment.

Requirements

PhD, PharmD, or MD in Clinical Pharmacology, PK/PD, Pharmaceutical Sciences, or related field
5–10+ years industry experience (Director) or 10+ years (Sr Director) applying CP in drug development
Direct experience with monoclonal antibodies/biologics, including immunogenicity and TMDD
In depth knowledge in contemporary PK, population PK, QSP modeling concepts, data analysis, and interpretation; demonstrated record in applying these concepts to support pre-clinical and clinical development programs.
Proficiency with PK/PD, E-R, and PMx tools (e.g., WinNonlin, NONMEM/Monolix, R).
Strong understanding of bioanalytical guidance and GLP/GxP regulations and regulatory expectations for CP across IND through BLA/MAA
Previous experience working on INDs
Excellent communication, cross-functional collaboration, and leadership capabilities
Vendor management and experience working in fast-paced, matrixed biotech environments

Responsibilities

Develop and oversee clinical pharmacology strategy for biologics programs across all stages of development
Serve as the CP lead on nonclinical and clinical project teams, providing scientific input on study design, dose selection, PK/PD, and E-R
Lead first-in-human dose selection, PK/PD analyses, including NCA, PopPK/PD, and modeling/simulation
Collaborate with external CRO partners to deliver quantitative support for program decisions
Contribute and author CP content to protocols, SAPs, CSRs, and regulatory submissions (INDs, briefing packages, BLA sections)
Partner cross-functionally (Clinical, Regulatory, Stats, Translational, Nonclinical) to integrate CP into development plans
Establish and maintain CP standards, templates, and oversight of bioanalytical and modeling vendors
Present findings internally and externally with scientific meeting abstracts, posters, and manuscripts

Benefits

Market leading compensation
401K with 100% employer match on first 3% & 50% on the next 2%
Employee stock purchase program
Pre-tax commuter benefits
Referral program with $2,500 award for hired referrals
Comprehensive health care with 100% premiums covered - no cost to you and dependents
Mental health support via Spring Health (6 therapy sessions & 6 coaching sessions)
Hybrid work model - employees have the autonomy in where and how they do their work
Unlimited flexible paid time off - take the time that you need
Paid parental leave - 4 months for birthing parents & 2 months for non-birthing parents
Flex spending accounts & company-provided group term life & disability
Subsidized lunch via Forkable on days worked from our office
People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility
We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, Spring Health & BetterUp Coaching
We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities