Director/Senior Director Translational Bioinformatics

Gossamer Bio • San Diego, CA

4h

About The Position

Gossamer Bio has an outstanding opportunity for a motivated and accomplished computational biology leader to join our lean Translational Science team. We are seeking a visionary bioinformatics leader who thrives at the intersection of biology, technology, and data science. This is a chance to build and drive cutting-edge translational bioinformatics, leveraging AI/Machine Learning and multi-omics innovation to transform clinical development and precision medicine. The successful candidate will join a biotech environment that values creativity, impact, and rapid execution, and will partner closely with Translational Medicine, Research, and Clinical Development teams to shape the next generation of patient-centric therapeutics.

Requirements

• Ph.D. (or equivalent experience) in computational biology, bioinformatics or biostatistics with 10+ years of biotech industry experience and a strong publication record in peer-reviewed journals.
• Expertise in next-generation sequencing algorithms, pipelines and applications (including single cell genomics)
• Strong coding skills (eg. R, Python) with an excellent working knowledge of public bioinformatics databases, emerging technologies and reproducible research practices.
• Experience in pulmonary disease, fibrosis, inflammation, immunology and/or cardiovascular biology.
• Scientific curiosity and creativity, with an ability to identify questions that computational approaches can address, and the skills to develop solutions both independently and collaboratively.
• Demonstrated experience in evaluating and executing data science algorithms and machine learning/AI models.
• Proven ability to bridge computation and biology, with an entrepreneurial mindset and track record of driving innovation from concept to clinical impact.
• Strong communication (written and verbal), data presentation and visualization skills.
• Experience leading productive collaborative relationships, including remotely and across cultures.
• Comfortable communicating science and influencing strategic decisions at all levels.

Nice To Haves

• A deep understanding of biology and the drivers of human disease would be a plus.

Responsibilities

• Lead the analysis of clinical biomarker data by developing and executing exploratory biomarker analysis plans (genetics, proteomics, RNA‑seq/single-cell, imaging), including pre-specification of hypotheses, endpoints, and statistical methodologies
• Support clinical development programs by ensuring exploratory biomarker results, analyses and deliverables meet project timelines and regulatory-grade expectations, if applicable (data integrity, traceability, documentation)
• Collaborate with interdisciplinary teams (Clinical, Research, Biostats) to perform (hands-on) and/or direct multi-omics data analyses and integration across various domains and apply best-in-class algorithms to directly address the motivating biological and clinical questions.
• Drive innovation by applying advanced bioinformatics, data science, machine learning (ML) and Artificial Intelligence (AI) methods to interrogate high-dimensional datasets, enabling mechanism-of-action insights, drug response biomarkers, and data-driven patient stratification.
• Effectively lead bioinformatics CRO relationships by developing work plans, fostering efficient communication and ensuring high-quality deliverables.
• Translate complex findings into clear narratives for clinical teams, governance and external audiences (posters/manuscripts)
• Develop and scale the translational bioinformatics and AI platform and strategy, building a lean, high-impact team and external network to support future pipeline growth

Benefits

• Gossamer Bio offers highly competitive benefit plans and programs, including medical, dental and vision insurance, 401(k) and 401(k) matching , long-term incentive plan, disability plan, vacation pay, sick time, holiday pay, and work, personal and family time off in accordance with the terms of the applicable plans.
• For additional general information on Company benefits, please visit https://www.gossamerbio.com/work-at-gossamerbio/

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree
• Number of Employees: 101-250 employees