The Legal Director, R&D and Regulatory will serve as a trusted advisor providing expert legal counsel and strategic guidance across Alnylam’s Research & Early Development (ReDev), Regulatory, Global Patient Safety & Risk Management, and Data Science teams and support compliance with applicable laws and regulations, while enabling innovation in a fast-paced, science-driven environment. Reporting to the Executive Director, Head of R&D Legal this individual will operate in a highly collaborative matrix setting , partnering effectively across Alnylam’s Expertise Areas – and Legal and Compliance sub-functions (IP Legal, Corporate Transactions & Alliances Legal, Commercial Legal, Ethics & Compliance (E&C), Privacy) – to anticipate risks, identify opportunities and shape legal frameworks that support Alnylam’s R&D vision and growth. Aligned with the company’s R&D strategy, this role will particularly: Partner with Therapeutic Area (TA) Heads in Cardiometabolic Disease, Neuroscience (and future TAs) to maintain strong program governance and provide support across the product development spectrum (e.g., preclinical, clinical development), including guidance on FDA / ex-US regulations and interactions with agencies, lifecycle management, GCP compliance, data privacy, collaborations with investigators, and data dissemination; Support initiatives to accelerate growth in existing franchises through internal and external innovation, including by collaborating with IP Legal and Corporate Transactions & Alliances Legal on academic partnerships, technology evaluations, and other research efforts; Help build research capabilities in complementary modalities that extend the reach of genetic medicines as Alnylam scales; Collaborate with the Quantitative Sciences group and the IT Expertise Area on advanced analytics, real-world data, and AI-driven initiatives; Provide partnership to Legal colleagues supporting clinical pipeline delivery and trial execution.