Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences
About The Position
AstraZeneca is seeking a highly motivated and passionate Director, Project Toxicologist to join their Oncology Targeted Delivery (OTD) Safety group. The company's mission is to eliminate cancer as a cause of death, and the OTD Safety team is crucial in accelerating transformative therapies to patients. This role focuses on novel targeted oncology therapies, including Radio Conjugates, Antibody Drug Conjugates (ADCs), and Small Molecules. The successful candidate will partner with cross-functional teams across Oncology R&D, bridging discovery and regulatory toxicology, driving innovative safety strategies, and accelerating drug development. The role involves applying toxicology expertise to inform candidate selection, guide regulatory strategy, and define the future of oncology safety science.
Requirements
- PhD and/or DABT in Toxicology, Pharmacology, Oncology, or related fields with a strong scientific track record.
- 10+ years’ experience in Project Toxicology, Investigative Toxicology, or related safety-focused roles in pharma, biotech, or CRO environments.
- Deep understanding of oncology drug discovery and development, with proven ability to deliver toxicology programs supporting IND filings.
- Skilled in using in vitro, in silico, and in vivo tools to predict clinical safety risks.
- Collaborative, problem-solving mindset with the ability to coordinate across multiple projects and geographies.
- Strong communication, interpersonal, and influencing skills to inform decisions across scientific and regulatory teams.
- Commitment to inclusion, diversity, and team development, supporting AstraZeneca’s Great Place to Work objectives.
Nice To Haves
- Expertise in Radio Conjugates or ADCs preferred, with familiarity in small molecule oncology therapeutics.
Responsibilities
- Lead regulatory and investigative toxicology study design, developing strategies to predict, assess, and mitigate target- and modality-related safety risks.
- Apply your toxicology expertise to predict clinical safety risks and support data-driven decisions across discovery and development programs.
- Innovate at the intersection of regulatory toxicology and cutting-edge science, leveraging in vitro, in silico, in vivo, and emerging technologies like organ-on-chip, imaging, and omics.
- Communicate integrated risk assessments to governance bodies and contribute to regulatory submissions.
- Maintain and expand expertise in regulatory standards, preclinical safety, and modality-specific safety science, staying ahead of industry trends.
- Provide strategic toxicology input for in-licensing evaluations and external collaborations.
- Drive Oncology Safety science through internal and external collaborations, publications, and thought leadership.
Benefits
- qualified retirement program [401(k) plan]
- paid vacation and holidays
- paid leaves
- health benefits including medical, prescription drug, dental, and vision coverage
- short-term incentive bonus opportunity
- eligibility to participate in our equity-based long-term incentive program (salaried roles)
- eligibility to receive a retirement contribution (hourly roles)
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What This Job Offers
Job Type
Full-time
Career Level
Director
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
