Director, Pharmacometrics

Crinetics Pharmaceuticals • Headquarters, KY

5d

About The Position

The Director of Pharmacometrics will support Crinetics’ translational and early clinical programs by applying mechanistic and quantitative modeling to guide decision-making from compound nomination through first‑in‑human studies. This role involves conducting PBPK and/or QSP modeling directly or working with external partners on a case‑by‑case basis to integrate preclinical, in vitro, biomarker, and early clinical data into predictions that inform IND‑enabling work, dose selection, and study design. Working closely with translational development, DMPK, biology, toxicology, and clinical teams, the Director will help identify quantitative needs at key development milestones and ensure modeling results are translated into clear, actionable insights. In addition to mechanistic modeling activities, the Director will provide scientific review and strategic input on population PK, PK/PD, and exposure–response analyses performed internally or through CRO partners. This position is well‑suited for a scientist who enjoys hands‑on modeling balanced with coordinated vendor support, and who thrives in a collaborative cross‑functional environment.

Requirements

• Pharm.D/Ph.D. or MS in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a strong understanding of clinical pharmacology principles.
• Significant industry experience (Director: MS and 10+ years of experience) in clinical pharmacology data analysis and interpretation.
• Experience with PBPK modeling, QSP modeling, and/or integration of AI/ML into clinical pharmacology decision-making.
• Experience interpreting and overseeing population PK and exposure–response analyses.
• Familiarity with all stages of clinical drug development, including experience in the preparation of components of the Clinical Pharmacology sections of Regulatory submissions for IND- and NDA-stage projects.
• Experience working in a cross functional team and matrix environment.
• Strong written, presentation and verbal communication skills.
• Ability to influence business leaders at all levels.
• Critical thinker with strong problem-solving skills.
• Demonstrated leadership, strategic thinking, collaboration, and management skills to oversee and develop in-house pharmacometrics capabilities.

Responsibilities

• Lead mechanistic modeling (PBPK and/or QSP) to support IND‑enabling decisions, FIH dose selection, and early clinical strategy.
• Integrate preclinical, in vitro, biomarker, and early clinical data to generate human PK/PD and dose predictions.
• Partner with translational development, DMPK, biology, tox, and clinical teams to anticipate quantitative needs across key decision points.
• Provide strategic oversight of population PK, PK/PD, and exposure–response analyses conducted internally or by CROs.
• Inform efficient study designs using mechanistic and empirical modeling to guide dose selection, sampling, and biomarker strategy.
• Develop and review program‑level quantitative analysis plans.
• Synthesize modeling results into clear, actionable insights for project teams and governance.
• Contribute modeling content to regulatory submissions (e.g., INDs, NDAs, IBs).
• Support departmental objectives, mentor staff, and help build internal mechanistic and translational modeling capabilities.
• Strong written, presentation and verbal communication skills.
• Other duties as assigned.

Benefits

• discretionary annual target bonus
• stock options
• ESPP
• 401k match
• health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance
• 20 days of PTO
• 10 paid holidays
• winter company shutdown

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree