Director of Toxicology
About The Position
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. The Director, Toxicology will play a critical role in supporting the nonclinical safety assessment of therapeutics within Denali's pipeline. This position involves conducting and managing toxicology studies, analyzing and interpreting safety data, and collaborating with cross functional teams to advance drug candidates through various stages of development.
Requirements
- PhD in Toxicology, Biology, Pharmacology or related scientific discipline
- 15+ years of biotech/pharmaceutical drug discovery/development experience
- Strong scientific background and scientific aptitude
- Excellent critical thinking and scientific skills
- Ability to work effectively and collaboratively on cross-functional projects teams, and demonstrated can-do attitude
- Ability to work in a fast-paced environment
- Excellent oral, presentation, and written communication skills
Nice To Haves
- Experience with biologics and oligonucleotides preferred
Responsibilities
- Design and implement nonclinical toxicology programs and strategies to evaluate the safety of Denali's therapeutic candidates.
- Conduct and oversee non-GLP and GLP toxicology studies, ensuring adherence to regulatory standards.
- Analyze, interpret, and summarize toxicology data to support safety evaluations.
- Prepare and present safety data to internal project teams and senior management, contributing to informed decision-making.
- Assist in the preparation and authoring of regulatory documents related to nonclinical safety assessments.
- Ensure compliance with relevant regulatory guidelines and standards throughout all stages of toxicology studies.
- Work closely with colleagues in Research and Development, providing toxicology expertise to support cross-functional project teams.
- Participate in project meetings, offering insights and recommendations to advance safety assessment strategies.
- Support investigative efforts into mechanisms of toxicity and contribute to the development of safer therapeutic candidates.
- Assist in developing and implementing de-risking strategies for drug discovery and development projects.
Benefits
- Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
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What This Job Offers
Job Type
Full-time
Career Level
Director
Industry
Professional, Scientific, and Technical Services
Education Level
Ph.D. or professional degree
Number of Employees
251-500 employees
