Director, Epidemiology

Revolution Medicines

5h • Remote

About The Position

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
The Director, Epidemiology is responsible for execution of epidemiology plans and activities for Revolution Medicines assets. They will work across the clinical development, safety, medical affairs, and commercial matrix leading the execution of key epidemiology deliverables. Reporting to the Executive Director, Head of Epidemiology & RWD Strategy, they will closely align with the Global Patient Safety organization to provide epidemiologic context to potential safety signals, inform the benefit/risk of Rev Med products, and contribute to the design and execution of post-approval safety studies, globally. This is an exceptional opportunity to contribute to the advancement of oncology by generating innovative epidemiology and real-world evidence that will shape the future of patient care.
The Director, Epidemiology will lead the execution of epidemiology strategy for a given asset and/or indication, including executing epidemiology plans for key studies (e.g., systematic literature reviews, natural history studies, clinical trial design and optimization, comparative effectiveness and safety, and healthcare resource utilization types of studies).
Designs and executes deliverables in accordance with the plan, either personally or through oversight of other epidemiologists/vendors/contractors; this may involve the development of templates and SOPs, as well as authoring protocols, SAPs, clinical study reports, slide decks, abstracts, posters, and peer-reviewed manuscripts.
Provides epidemiology support to Clinical Development, Global Patient Safety, Regulatory Affairs, Medical Affairs, and Commercial activities across the medicines development life cycle. Active participation on cross-functional teams.
Ensures epidemiology point of view is included in key deliverables from other functions such as clinical trial protocols, SAPs, case report forms, regulatory submissions, and payer interactions within assigned indications and/or assets.
Interacts with authors and in-house reviewers on scientific manuscripts, clinical conference abstracts, presentations, and posters based on observational study data.
Appraises and synthesizes relevant epidemiological and RWE literature and regulatory guidance documents.

Requirements

• PhD / DSc / DrPH in epidemiology or a relevant advanced science degree and at least 10 years of related industry experience at a sponsor/pharmaceutical company.
• Demonstrated technical knowledge of pharmacoepidemiologic methods and real-world oncology data sets as well as the use of appropriate biostatistical methods.
• Excellent analytic and problem-solving skills.
• Excellent attention to detail and quality, and scientific rigor.
• Strong interpersonal skills and the ability to work effectively in matrix teams.

Nice To Haves

• 10+ years of oncology pharmacoepidemiology experience at a sponsor/pharmaceutical company.

Responsibilities

• Lead the execution of epidemiology strategy for a given asset and/or indication, including executing epidemiology plans for key studies (e.g., systematic literature reviews, natural history studies, clinical trial design and optimization, comparative effectiveness and safety, and healthcare resource utilization types of studies).
• Designs and executes deliverables in accordance with the plan, either personally or through oversight of other epidemiologists/vendors/contractors; this may involve the development of templates and SOPs, as well as authoring protocols, SAPs, clinical study reports, slide decks, abstracts, posters, and peer-reviewed manuscripts.
• Provides epidemiology support to Clinical Development, Global Patient Safety, Regulatory Affairs, Medical Affairs, and Commercial activities across the medicines development life cycle. Active participation on cross-functional teams.
• Ensures epidemiology point of view is included in key deliverables from other functions such as clinical trial protocols, SAPs, case report forms, regulatory submissions, and payer interactions within assigned indications and/or assets.
• Interacts with authors and in-house reviewers on scientific manuscripts, clinical conference abstracts, presentations, and posters based on observational study data.
• Appraises and synthesizes relevant epidemiological and RWE literature and regulatory guidance documents.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree