Director, Computational Chemistry

Revolution Medicines • Redwood City, CA

297d • $204,000 - $255,000

About The Position

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Playing a critical role as the leader of Computational Chemistry responsible for: Guide the strategy for expanding the capabilities of structure based drug design within RevMed’s unique mode of action. Managing, coaching and mentoring scientists across the computational chemistry function in order to develop their skills and build RevMed’s organizational capabilities. Being a partner in the scientific activities of other outstanding scientists across Revolution Medicines and helping create an environment where we channel scientific curiosity to build and deliver a sustainable portfolio. Advancing the RevMed Research Portfolio and helping build our scientific reputation through presentation/publication of project results in scientific meetings and peer-reviewed literature, as guided by RevMed publication policies, to build our scientific reputation. Identifying, establishing and leading partnerships with selected strategic technology partners focused on supporting RevMed projects.

Requirements

• A Ph.D. degree in a relevant scientific discipline.
• Over 5+ years’ experience in the pharmaceutical/biotech industry.
• Strong track record of positive impact in programs.
• Expertise in a broad variety of computational techniques, particularly molecular docking, pharmacophore development, library design and analysis, machine learning methods, and protein-protein/protein-ligand simulation.
• Experience in identifying hits and leads against challenging targets using state-of-the-art in silico methodology.
• Recognized as an intellectual leader in the early phases of drug discovery.
• Demonstrated ability to recognize anomalous and inconsistent results and interpret experimental outcomes.
• Demonstrated ability to plan and achieve research goals as part of an interdisciplinary team.
• Knowledge of oncology therapeutic area and drug discovery.
• Excellent written and verbal communication skills.
• Evidence of successful coaching, mentorship and development of both individuals and teams.

Nice To Haves

• Demonstrated ability to plan and achieve research goals as part of an interdisciplinary team.
• Knowledge of oncology therapeutic area and drug discovery.

Responsibilities

• Guide the strategy for expanding the capabilities of structure based drug design within RevMed’s unique mode of action.
• Manage, coach and mentor scientists across the computational chemistry function.
• Partner in the scientific activities of other scientists across Revolution Medicines.
• Advance the RevMed Research Portfolio and build scientific reputation through presentations/publications.
• Identify, establish and lead partnerships with selected strategic technology partners.

Benefits

• Competitive cash compensation
• Robust equity awards
• Strong benefits
• Significant learning and development opportunities

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree