Director, Commercial Supply Chain Planning and Operations

Zenas BioPharma • Waltham, MA

19h • Hybrid

About The Position

The Commercial Supply Chain Planning and Operations Director will play a pivotal role in leading commercial planning and execution for Zenas’ first commercial product in the U.S. and the EU. This individual will be responsible for developing and maintaining end-to-end commercial supply plans, production schedules, and inventory strategies to ensure seamless product availability at launch and beyond. In addition, this individual will lead cross-functional launch planning and readiness activities to ensure operational and supply chain readiness for successful product launch in both the U.S. and EU. This role will collaborate closely with Commercial, Technical Operations, Quality, Regulatory Affairs, CMC, and Finance, as well as external partners and CDMOs. The successful candidate will actively lead and drive the Sales & Operations Planning (S&OP) process for the commercial portfolio, develop and maintain performance metrics, and lead scenario modeling to optimize supply strategies aligned with regulatory filings, market forecasts, and business objectives

Requirements

• Bachelor’s degree in Supply Chain, Engineering, Life Sciences, or a related field (MBA or advanced degree preferred).
• Minimum of 12+ years in biotech or pharmaceutical supply chain management, with 3+ years in commercial or late-stage launch readiness.
• Proven experience managing CDMO relationships and external manufacturing operations (Drug Substance, Drug Product and Packaging and Labeling).
• Hands-on expertise in supply planning, launch planning, forecasting, and S&OP processes.
• Strong understanding of GMP manufacturing, regulatory submission impact on supply, and global distribution logistics.
• Excellent analytical and modeling skills; advanced skills in Excel and/or supply planning tools.
• Strong project management and cross-functional leadership capabilities.
• Exceptional communication and presentation skills, with the ability to synthesize complex information for senior stakeholders.
• Demonstrated ability to thrive in a fast-paced, dynamic, and matrixed environment.
• Comfortable managing ambiguity and building new processes from the ground up.
• Ability to work flexible business hours to travel and communicate with global business partners (up to 10-20% of time).

Responsibilities

• Lead cross-functional commercial supply and launch readiness activities for the first product launch in the US and EU.
• Develop, drive and maintain detailed launch plans ensuring overall supply chain and CMC readiness for commercial launch.
• Build and maintain commercial supply models, forecasts, and capacity plans based on market demand, inventory strategies, and lead times.
• Coordinate with CDMOs to establish production schedules, campaign plans, and batch execution aligned to forecast requirements and contractual commitments.
• Lead monthly supply planning reviews and provide input into the S&OP process, highlighting risks, opportunities, and recommended actions.
• Partner with CMC, Quality, Regulatory, and Commercial to align supply strategies with registration timelines, market access, and forecast assumptions.
• Track and report key supply performance metrics (e.g., service level, plan adherence, capacity utilization, inventory health). Develop and implement supply chain dashboards, reports, and KPIs to support executive decision-making.
• Partner with Quality and Technical Operations to ensure compliant product release and distribution readiness.
• Support cost and budget management for commercial supply chain activities, including scenario-based financial impact modeling.
• Contribute to continuous improvement initiatives for planning systems, tools, and processes.

Benefits

• The position is eligible for a competitive compensation and benefits package.
• Our base salary is just one component of Zenas’ competitive total rewards strategy that also includes annual performance bonus, equity, full range of benefits and other incentive compensation plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Number of Employees: 101-250 employees