Director, Clinical Trial Finance

Structure Therapeutics•South San Francisco, CA

About The Position

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions. Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location. The Director, Clinical Trial Finance will lead financial planning and oversight of clinical trial activities, including accruals, in support of the company’s development portfolio. Reporting to the Executive Director, FP&A, this role serves as a key strategic partner to Clinical Operations, Development, FP&A, and Accounting, ensuring strong financial governance, accurate reporting, and actionable insights to inform decision-making. The ideal candidate brings deep expertise in biotech finance, a thorough understanding of clinical development, and a strategic, hands-on approach to driving financial performance in a dynamic, growth-oriented environment. This is an opportunity to play a critical role in advancing a global, publicly traded biotech company’s pipeline and supporting the successful execution of clinical programs.

Requirements

10+ years of finance experience, including 7+ years in increasingly responsible roles within finance and accounting, with significant experience supporting clinical trials in the biotech or pharmaceutical industry.
Deep industry experience with strong understanding of clinical development, industry dynamics, and key financial drivers.
Strong knowledge of GAAP and SOX compliance, with deep expertise in accrual accounting and clinical trial financial management, including contracts and CRO oversight.
Proven leadership experience with a track record of building and developing high-performing teams.
Advanced financial modeling and forecasting capabilities, including scenario planning and analysis.
Strong analytical, strategic thinking, and problem-solving skills.
Excellent communication and interpersonal skills, with the ability to influence cross-functional stakeholders and external partners.
Proficiency in financial systems and Microsoft Office Suite.
Bachelor’s degree in Finance, Accounting, or a related field required.

Nice To Haves

Experience supporting global clinical trials and managing financials across multiple currencies.
Experience with NetSuite, Zip, and Condor preferred.
Strong project management skills with the ability to manage multiple priorities in a fast-paced environment.
CPA or MBA preferred.

Responsibilities

Lead, mentor, and scale the Clinical Trial Finance function, including direct management of the Senior Clinical Trial Finance Manager.
Drive financial planning, budgeting, forecasting, and long-range planning for clinical trials; oversee financial management across programs, including accruals and variance analysis, in alignment with corporate objectives.
Oversee financial management of clinical trial contracts, amendments, and compliance with financial terms.
Partner closely with Accounting to ensure accurate and timely financial close processes, including journal entries, reconciliations, and reporting of clinical trial costs.
Serve as the primary finance business partner to Clinical Operations, Development, and Program Management, providing insights and ad hoc financial reporting to support decision-making.
Establish and maintain strong relationships with Contract Research Organizations (CROs), vendors, and external partners.
Lead audit readiness efforts and support internal and external audits related to clinical trial expenditures.
Continuously enhance financial processes, systems, and internal controls to support scalability and operational excellence.