Director, Clinical Pharmacology Lead

Janux Therapeutics•San Diego, CA

33d•$232,000 - $254,000•Onsite

About The Position

Janux Therapeutics is seeking a hands-on, execution-driven Clinical Pharmacology Lead to support the design, analysis, and interpretation of clinical pharmacology strategies across our development programs. This role is ideal for a scientific contributor who thrives on working directly with data, ensuring high-quality PK analysis, and enabling data-informed decisions for dose selection and regulatory filings. This position is focused on executional excellence, not modeling ownership. PK/PD modeling and simulation may be supported externally, while this role ensures internal strategic alignment and scientific rigor in clinical pharmacology deliverables.

Requirements

Ph.D., Pharm.D., or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related field.
6+ years of experience in clinical pharmacology and/or pharmacometrics in the biotech or pharmaceutical industry.
Direct experience designing and executing early-phase clinical studies, including healthy volunteer studies.
Strong expertise in PK analysis and exposure-response interpretation; experience in oncology or biologics preferred.
Familiarity with T cell engagers (TCE) and managing external Clinical Pharmacology resources.
Proven track record of contributing to regulatory submissions and engaging with health authorities.
Excellent communication, collaboration, and organizational skills.
Ability to work independently and in a fast-paced, matrixed environment.
Ability to travel up to 15%

Responsibilities

Serve as the Clinical Pharmacology Lead across multiple programs, owning the execution of clinical pharmacology plans from IND through early clinical development.
Design and oversee PK, PK/PD, and exposure-response analyses to support dose selection, study design, and benefit-risk assessments.
Lead the development and execution of clinical pharmacology components of studies, including food effect, drug-drug interaction, organ impairment, and QT assessments.
Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs, briefing books) and support regulatory interactions.
Ensure proper bioanalytical sampling strategies, assay validation, and data quality across studies.
Collaborate with Translational Medicine and Biomarker teams to integrate mechanistic and biomarker data into PK/PD interpretation.
Work closely with Biometrics and external modeling partners to support population PK and exposure-response modeling.
Stay current with regulatory guidance and scientific advances in clinical pharmacology, applying best practices to development programs.
Contribute to program-level planning and prioritization based on pharmacological insights and development risk.
Other activities as required.