Director, Biostatistics

Vor Bio•Boston, MA

2d•$230,000 - $250,000

About The Position

At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first- and potentially best-in-class dual BAFF/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide. When you join Vor, you’re not just working on a medicine. You’re part of a mission to redefine the future of autoimmune care. The Director, Biostatistics serves as a senior individual contributor to statistical leadership at Vor Biosciences, providing strategic and operational oversight across multiple clinical programs. Reporting to the Head of Biometrics this individual will serve as Vor's global expert in biostatistical science, with accountability for all aspects of clinical trial design, statistical methodology, regulatory submission deliverables, and cross-functional scientific partnership. This is a hands-on, high-impact role in a lean, mission-driven biotech environment where the Director will function as a study and program statistical lead with both technical depth and enterprise-wide strategic influence.

Requirements

PhD in Biostatistics, Statistics, or a closely related quantitative discipline strongly preferred.
Master's degree (MS/MA) in Biostatistics or Statistics with extensive industry experience may be considered.
Minimum 10 years of pharmaceutical/biotech industry experience in clinical biostatistics, with at least 5 years in a senior or program-lead capacity.
Demonstrated program-level statistical ownership from protocol design through regulatory submission (IND, NDA/BLA, or MAA).
Hands-on experience with adaptive designs, Bayesian methods, or novel estimand frameworks (ICH E9(R1)).
Track record of direct FDA and/or EMA interaction, including preparation and response to agency queries.
Experience managing CRO statistical and programming relationships and vendor deliverable quality.
Proficiency in SAS (required); R strongly preferred; Python or additional statistical languages a plus.
Familiarity with CDISC standards (SDTM, ADaM), eCTD submission requirements, and reviewer's guide preparation.
Demonstrated ability to communicate complex statistical concepts clearly and concisely to diverse audiences — including clinical, regulatory, and executive stakeholders — through both compelling written deliverables and confident oral presentations.
Exceptional statistical reasoning with ability to translate complex methodology into clear language for non-statistical audiences.
Strong leadership and cross-functional influence without requiring direct line authority over all stakeholders.
Comfort operating in a lean, fast-paced biotech with hands-on execution alongside strategic thinking.
Ability to build statistical processes, standards, and infrastructure from the ground up.
Excellent written and oral communication; effective across regulatory, executive, and scientific forums.
Strong project management skills; able to manage multiple programs simultaneously under tight timelines.
Collaborative, patient-centered mindset aligned with Vor's mission in hematologic disease.

Nice To Haves

Background in rare disease, hematology, oncology, or cell/gene therapy development.
Experience with small-sample trial design methodologies (e.g., single-arm studies, external control arms, Bayesian borrowing, historical data integration).
Prior experience at a clinical-stage biotech with responsibility for building or scaling a biometrics function.