Development Scientist III, Viral Vector Analytical Development

AstraZeneca • Boston, MA

2d • Onsite

About The Position

Are you ready to make a significant impact in the field of genomic medicine? As a Development Scientist III in Viral Vector Analytical Development at Alexion, you will be at the forefront of advancing our genomic medicine portfolio. Collaborate with a dynamic team of scientists and engage with the Genomic Medicine and Viral Vector Product Development groups to develop and optimize methods for assessing recombinant Adeno-Associated Virus (rAAV) viral vectors. Your expertise will drive innovation and contribute to regulatory submissions, ensuring the success of our cutting-edge therapies.

Requirements

• BS in Molecular Biology, Biochemistry, or related field with 10+ years of relevant experience, a MS with 8+ years of experience, or PhD with 4+ years of experience.
• Strong hands-on experience in the development, qualification/validation, and transfer of biochemical and biophysical (liquid chromatography, dynamic and multi-angle light scattering, capillary gel electrophoresis, imaged capillary isoelectric focusing) methods for assessing viral vectors and/or rAAV products.
• Demonstrated ability to utilize standard office software (Excel, PowerPoint, Word, etc.), data analysis software (Chromeleon, Empower, OpenLab, JMP, etc.), and eNotebooks software.
• Strong analytical mindset and problem-solving skills.
• Superior organizational and time management skills, ability to prioritize multiple demands and work efficiently with great attention to detail.
• Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment.
• The duties of this role are conducted in a mixed office and lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift 15 pounds unassisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

Nice To Haves

• Prior experience with mass spectrometry, surface plasmon resonance, mass photometry, analytical ultracentrifugation or other extended protein characterization techniques is a plus.
• Candidates should be self-starters, comfortable with autonomy, and embrace opportunities to develop new genomic medicines as part of a dynamic team within Alexion.

Responsibilities

• Develop, optimize, and implement biochemical and biophysical methods to quantify product and process impurities and perform extended protein characterization of rAAV vectors.
• Design and execute experiments, review and analyze data, and qualify assays in lab activities.
• Support tech transfer of biophysical assays to internal teams and external manufacturing/testing organizations for release and characterization testing; serve as subject matter expert for assay troubleshooting and lab investigations.
• Develop presentations for internal and external audiences, author and review SOPs, technical reports, and assist with analytical sections for regulatory submissions (IND, BLA, etc.).
• Serve as analytical lead on cross-functional CMC teams, collaborating with QC, Upstream/Downstream Process Development, Manufacturing, QA, and Regulatory teams to execute genomic medicine analytical strategy.

Benefits

• positions offer a short-term incentive bonus opportunity
• eligibility to participate in our equity-based long-term incentive program (salaried roles)
• to receive a retirement contribution (hourly roles)
• commission payment eligibility (sales roles)
• Benefits offered included a qualified retirement program [401(k) plan]
• paid vacation and holidays
• paid leaves
• health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees