CONTRACTOR Sr. Research Associate/Associate Scientist, Analytical Development

Poseida Therapeutics • San Diego, CA

109d • $28 - $53

About The Position

We are seeking an experienced and motivated Associate to join the Analytical Development team. This position works with the PTCC team to develop and/or improve cell-based assays for cell product characterization and release. The Analytical Development Associate participates in laboratory activities to support process development, evaluate and develop new assay methods, and perform product characterization for CAR-T cell products. He/she is also involved in assay optimization and standardization and assay transfer to internal or external QC labs. Under reasonable supervision, the role includes performing assay development experiments, carefully documenting methods and materials, writing SOPs/reports, and communicating findings. The ideal candidate has a proven track record of innovation, demonstrated skill set and knowledge in process and analytical development, and is excited to take on new challenges in a fast-paced and dynamic environment.

Requirements

• BS or MS degree in a relevant scientific discipline with two plus years of relevant experience in a biotech environment (an equivalent combination of education and experience may be considered).
• Experience in human T cell biology with demonstrated proficiency in a broad range of cellular immunology techniques, including flow cytometry.
• Experiences with aseptic cell culture (human primary cells and cell lines) and bio-assay development and/or testing.
• Ability to follow laboratory procedures with attention to detail, and successfully execute experiments at the bench.
• Demonstrated ability to maintain detailed lab execution records and perform data analysis.
• Excellent communication skills, data presentation and interpersonal skills.
• Basic computer skills in Excel, PowerPoint, and word processing.
• Attention to detail, initiative, and strong organizational skills.
• Demonstrated ability to work in a fast-paced small company environment with reasonable direction and able to adjust workload based upon changing priorities.

Nice To Haves

• Minimum of two plus years of relevant industry experience.
• Foundation in experimental documentation, basic statistical analysis, and data presentation.
• Exposure in vitro T cell functional assays (potency, cytotoxicity, ELISA, proliferation, Luminex).
• Basic skills in molecular techniques including qPCR or ddPCR and electrophoresis.
• Experience with drafting SOP and forms.
• Develops assays for cell product release and characterization by designing and executing studies via design of experiment (DoE).

Responsibilities

• Develops analytical test method procedures in accordance with relevant guidelines from ICH, USP, EP for cell therapy product GMP release testing and characterization.
• Supports analytical routine testing, qualification, and validation.
• Evaluates reagents and supplies to meet QC standards.
• Co-authors test methods (SOPs), technical reports, and analytical sampling plans.
• Documents laboratory procedures and experiments with great attention to detail in laboratory notebooks.
• Performs assays for process assessment and product characterization.
• Participates in assay transfers to QC and provides lifecycle support.
• Evaluates alternative technologies to create robust and reproducible analytical methods.
• Sets up, monitors, samples, and analyzes cell culture processes.
• Works with R&D teams to gain deeper understanding of the analytical methods for characterization of product critical quality attributes.

Benefits

• Excellent career development opportunities.
• Highly competitive compensation.
• Comprehensive benefits.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Industry: Professional, Scientific, and Technical Services
• Education Level: Bachelor's degree