Computational Chemistry Senior Research Scientist

Vertex Pharmaceuticals • San Diego, CA

257d

About The Position

We are seeking a highly motivated Computational Chemistry Senior Research Scientist to join Vertex's research site in San Diego, California. This individual will be responsible for contributing to both lead identification and optimization programs using methods encompassing all computational aspects of drug discovery. This individual will work collaboratively with interdisciplinary project teams to provide expertise in cheminformatics, physics-based methods, and molecular design to deliver drug candidates. Contributing to improving foundational computational capabilities across the department is preferred and achieved through collaboration with the global DCS group.

Requirements

• Ph.D. (or equivalent degree) in engineering, science or math and 2-5 years of productive, relevant post-doctoral employment experience, or
• Master's Degree (or equivalent degree) in similar fields and 5+ years of productive, relevant employment experience, or
• Bachelor's Degree (or equivalent degree) in similar fields and 8+ years of productive, relevant employment experience
• Strong experience in applying molecular modeling methods to structure, ligand and fragment-based drug discovery
• Expert knowledge of the state-of-the-art for computational chemistry and its application in drug discovery, such as FEP and ML techniques
• Experience with commercial molecular modeling and data mining software
• Excellent oral and written communication skills
• Ability to multi-task and set priorities on multiple projects

Nice To Haves

• Expertise with a wide array of computational methods preferably including structure and ligand-based virtual screening, programming, statistics, data analysis, QSAR derivation and application, and ADME modeling

Responsibilities

• Collaborate with scientists at our San Diego drug discovery site and across our network to maximize the impact of computational efforts on drug discovery projects
• Ensure effective interdepartmental communication and implementation of in-silico work streams related to drug discovery
• Work with others in Computational Drug Design and the Chemical Data Science group to identify and apply new methodologies to increase impact of computation on drug discovery teams
• Incorporate innovative strategies and methodologies to address critical project issues

Benefits

• Medical, dental and vision benefits
• Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• Educational assistance programs including student loan repayment
• Generous commuting subsidy
• Matching charitable donations
• 401(k) and more

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree