Computational Biology, Associate Director

Amgen • South San Francisco, CA

205d • $190,424 - $229,244 • Remote

About The Position

The Computational Biology group in the Center for Technology and Innovation (CfTI) within the Precision Medicine organization at Amgen is seeking a highly motivated Computational Biologist with expertise in analyzing clinical biomarker data, including but not limited to metabolomics, genomics, transcriptomics, proteomics, spatial-omics, flow cytometry, immunoassays, and other biomarker assays. In this vital role, you will contribute to advancing Amgen's clinical programs and studies by integrating computational biology and bioinformatics techniques with biological and clinical data. The ideal candidate will have experience in matrixed environments, supporting therapeutic development by providing insights derived from clinical biomarker data. A background in cardiovascular diseases, obesity and chronic weight management, and other metabolic diseases is required.

Requirements

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 4 years of scientific experience OR Master's degree and 7 years of scientific experience OR Bachelor's degree and 9 years of scientific experience.

Nice To Haves

• PhD in Bioinformatics, Mathematics, Computer Science, Computational Biology or Data Science, with a minor or robust background in Biology and 8 years of scientific experience.
• Hands-on experience in statistical modeling, machine learning, and AI applied to clinical biomarker and clinical efficacy data.
• A strong understanding and practical skills in statistics and their use in data analysis for clinical settings.
• Proven expertise in analyzing multi-modal, multi-dimensional, and large-scale biological data.
• Prior experience working in a matrixed biotechnology or pharmaceutical setting.
• Proficiency in R and Python programming, with familiarity in various principles for data manipulation and visualization.
• Familiarity with agentic frameworks and the ability to build agents for day-to-day tasks that can be automated.
• Strong understanding of platforms used in clinical biomarker research, including pathomics, cytomics, immunoassays, mass-spectrometry, other metabolomics platforms, next-generation sequencing (NGS), and proteomics.
• Knowledge of inflammatory, cardiovascular and metabolic diseases and how computational biology can drive drug discovery and development in these areas.
• Ability to translate biological and medical questions into analytical models providing actionable results.
• Excellent written and oral communication skills with the ability to present complex data analyses in diverse settings, including cross-functional team meetings, external collaborations, and scientific publications.
• Strong project management skills and organizational awareness, self-motivation, independence, and leadership.

Responsibilities

• Support Amgen CVMet and OaR teams as a Global Biomarker Analysis Lead.
• Develop biomarker analysis plans to support precision medicine, evidence generation and reverse translation during clinical development of therapeutic molecules.
• Define and execute workflows for biomarker data analysis, integrating multiple omics, imaging and digital biomarkers, integrated with clinical metadata and outcomes.
• Lead the analysis and interpretation of clinical biomarker data from various assay platforms, including metabolomics, imaging, flow cytometry, immunoassays, transcriptomics, proteomics, and spatial omics.
• Support the generation of evidence for target engagement evaluation, patient stratification, response prediction, indication selection, assay development, and diagnostic development.
• Work closely with clinical scientists and biomarker leads, to extract biological insights from high-dimensional datasets and integrate them into translational analytics, precision medicine plans and clinical development plans.
• Collaborate cross-functionally with early development teams, biostatistics, clinical pharmacology, precision medicine leads, clinical biomarker leads, and research teams to manage data integration, analysis, and presentation.
• Support Amgen internal and external presentations with fit-for-purpose analysis insights and messaging and support the development of publications.

Benefits

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program.
• Stock-based long-term incentives.
• Award-winning time-off plans and bi-annual company-wide shutdowns.
• Flexible work models, including remote work arrangements, where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree