Co-op: In-Process Analytics

Prime Medicine • Cambridge, MA

8d • $23 - $33

About The Position

Prime Medicine is seeking a Fall 2026 co-op to join our Chemistry team, with a focus on in-process analytics and purification of large RNA molecules. The successful candidate will engage in hands-on laboratory work, including UV absorbance measurements using NanoDrop, purification support, sample analysis by UPLC and mass spectrometry (MS), and endotoxin testing of synthetic guide RNA. Through this experience, the co-op will develop proficiency in oligonucleotide characterization, gain exposure to a broad range of in-process analytical techniques, contribute to data generation and documentation, and present findings at weekly team meetings. We welcome curious, collaborative problem solvers who are passionate about advancing gene-editing technologies to improve human health.

Requirements

• Enrolled in a B.S. or M.S. program in Chemistry, Biochemistry, or a related field; basic knowledge of organic chemistry preferred
• Prior completion of general chemistry coursework and associated laboratory courses
• Strong written and oral communication skills, with excellent organizational ability and capacity to work both independently and collaboratively
• Enthusiasm for learning and contributing across multiple aspects of a research program

Nice To Haves

• Prior internship or co-op experience in a relevant setting
• Completion of analytical chemistry lecture and laboratory courses
• Hands-on experience in a chemistry laboratory, with familiarity with instrumentation such as HPLC, LC-MS, NanoDrop, and ÄKTA Pure

Responsibilities

• Support the characterization and purification of Prime's long guide RNA (gRNA) using a suite of laboratory techniques, including ÄKTA purifier, UPLC, LC-MS, NanoDrop, and endotoxin assays
• Integrate chromatograms for gRNA crude, fraction, and final samples in accordance with Prime's SOPs to quantify full-length product purity, and tabulate results in the team's electronic lab notebook
• Learn and contribute to mass analysis of gRNA to identify the molecular weight of the full-length product and related impurities
• Assist senior scientists with buffer preparation, instrument maintenance, and the development of updated analytical methods to expand in-process analytical capacity
• Manage inventory of critical reagents for buffer preparation in support of purification and analytics operations
• Coordinate with scientists to maintain inventory records for final released materials

Benefits

• A cutting-edge, mentorship-driven team with strong networking opportunities
• Full reimbursement for monthly commuting costs, including MBTA, Commuter Rail, and Bluebikes
• Access to regular seminars featuring industry experts
• Full participation in company-wide activities, including learning and development programming, social events, and more

What This Job Offers

• Career Level: Intern