Co-op, Discovery Biology, Cell-Based Assays

Scholar Rock • Cambridge, MA

17d

About The Position

Scholar Rock is a biopharmaceutical company that discovers, develops, and delivers life-changing therapies for people with serious diseases that have high unmet need. As a global leader in the biology of the transforming growth factor beta (TGFβ) superfamily of cell proteins and named for the visual resemblance of a scholar rock to protein structures, the clinical-stage company is focused on advancing innovative treatments where protein growth factors are fundamental. Over the past decade, the company has created a pipeline with the potential to advance the standard of care for neuromuscular disease, cardiometabolic disorders, cancer, and other conditions where growth factor-targeted drugs can play a transformational role.
Scholar Rock is the only company to show clinical proof of concept for a muscle-targeted treatment in spinal muscular atrophy (SMA). This commitment to unlocking fundamentally different therapeutic approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. By harnessing cutting-edge science in disease spaces that are historically under-addressed through traditional therapies, Scholar Rock works every day to create new possibilities for patients. Learn more about the company’s approach at ScholarRock.com and follow @ScholarRock and on LinkedIn.

Summary of Position:

Scholar Rock is seeking an outstanding individual to play an important role in the discovery and development of novel biotherapeutics for neuromuscular disorders. The successful candidate will join the Discovery Biology group to run cell-based assays and perform ex vivo tissue analyses to characterize novel antibody drug candidates. Through this position the candidate will be able to contribute to and learn about the drug discovery process.

Requirements

• Pursuing a BS or graduate degree (MS/PhD) in neuroscience, cell and molecular biology, biochemistry or related field with 1-2 years or more of laboratory experience
• Completed coursework in biochemistry and cell and molecular biology
• Hands on-experience with cell culture and aseptic laboratory techniques required
• Strong written and verbal communication skills
• The individual should be able to function in a timeline-driven, dynamic environment, and be able to rapidly adapt to new techniques and protocol
• A strong work ethic, scientific curiosity and a high-level of motivation are required
• The successful candidate should have the ability to work both independently and as part of a team to meet deadlines and contribute to the strategic goals of the company
• The candidate should demonstrate a willingness to learn and flexibility to work in a highly collaborative research organization

Nice To Haves

• Hands-on experience with RNA and protein-based techniques, like western blotting, ELISA, and qPCR, is preferred
• Experience with fluorescence microscopy and image analysis is a plus

Responsibilities

• Maintenance and expansion of mammalian tissue/cell cultures
• Execute complex multi-day cell-based assays with functional readouts including high-content imaging, ELISA, western blotting, and qPCR
• Support in vivo studies by performing RNA and protein-based tissue analyses
• Maintain detailed records of experimental protocols and data in laboratory notebooks in accordance with company policy
• Analyze, interpret and present experimental results in departmental meetings and company-wide poster symposium
• Read and summarize relevant primary literature for journal clubs
• Attend and engage in relevant group and team meetings

What This Job Offers

• Career Level: Intern