Co-op Biology-Oncology

Arvinas • New Haven, CT

20d • Onsite

About The Position

The Spring 2026 Oncology Biology Co-Op position at Arvinas will focus on evaluating the effect of novel heterobifunctional degrader molecules on intracellular oncology targets and on validating newly proposed targets for potential degrader discovery efforts. This position will involve cell biology and molecular biology techniques, and potentially new target proposition workflows. The candidate will join a collaborative, multi-disciplinary team of biologists, biochemists, biophysicists, and chemists. This is a laboratory-based role dedicated to validating novel oncology targets through functional and mechanistic studies, including the design and execution of in vitro cellular assays to establish the biological rationale for PROTAC-based therapeutic approaches. We are looking for a passionate and highly motivated individual who is enthusiastic about novel therapeutic applications, such as degraders, and wants to contribute to exploring new targets for degradation in the oncology space. This training opportunity allows the individual to learn the process of early drug discovery in a collaborative environment. This position reports to a Senior Research Investigator, Biology, Oncology and will be located at our headquarters in New Haven, CT.

Requirements

• The candidate should be a highly motivated fast learner with flexibility and ability to multi-task, as well as a good lab citizen.
• Experience in cell culture is required.
• Experience with immunoblotting and genetic perturbation assay skills are required.
• Prior lab experience highly preferred.
• Ability to work full-time (40 hours per week).
• Arvinas will not be providing VISA sponsorship for this position now or in the future.
• You must have the ability to work without a need for a current or future VISA sponsorship.
• The duties of this role are generally conducted in a lab environment.
• Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Nice To Haves

• Previous oncology experience is preferred
• Knowledge of ubiquitin-based proteasomal degradation is desired, but not a pre-requisite.
• Experience in the computational analysis and interpretation of omics datasets, such as RNA-seq and proteomics, to inform biological hypotheses, target identification, and mechanistic understanding is considered a plus.

Responsibilities

• Cell culture including sterile technique for mammalian cell lines
• Functional genomics approaches (such as CRISPR KO, siRNA/shRNA KD) to interrogate targets to understand their biological function, especially at scale or in a hypothesis-driven way
• Cellular assays to monitor activity of degrader compounds (such as Western blot, JESS, high-content imaging, HiBiT, NanoBRET)
• Establishing and developing new assays to detect target engagement and small molecule binding to targets in vitro and in cells
• Data analysis and interpretation, as well as presenting data in team meetings.
• Meeting with key stakeholders outside of the project team to devise future experiments for downstream applications

What This Job Offers

• Job Type: Full-time
• Career Level: Intern
• Number of Employees: 251-500 employees