Clinical Trial Manager

Candel Therapeutics•Needham, MA

10d•Hybrid

About The Position

We’re looking for a Clinical Trial Manager (CTM) to help us lead execution of our Phase 3 oncology trials with precision, confidence, and heart. This is a fast-paced, high-accountability role where you’ll collaborate cross-functionally, ensure inspection readiness, and keep our clinical operations running smoothly. If you’re a self-motivated leader who thrives on solving problems, navigating complexity, and working with humility, this role is for you.

Requirements

4+ years of CTM or site management experience in oncology clinical trials is required
Deep understanding of Phase 3 trial conduct and in-house operational models
Familiarity with ICH/GCP, FDA/EMA guidelines, and regulatory best practices
Strong leadership and problem-solving skills; ability to manage ambiguity and prioritize independently
Exceptional communication skills and comfort interacting with senior stakeholders
High emotional intelligence and a “scrappy but humble” mindset

Nice To Haves

Prior CRA experience is a plus

Responsibilities

Provide operational management and leadership to cross-functional study team to execute the clinical study per agreed upon timelines, budget and quality.
Drive startup through closeout: IRB, contracting, site selection, initiation, monitoring, and metrics tracking.
Support inspection readiness and contribute to critical regulatory milestones.
Co-monitor with CRAs; review site visit reports and escalate issues proactively.
Maintain essential documents and trial master file (TMF) accuracy.
Collaborate with internal teams and vendors to ensure alignment and effective execution.

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