Clinical Trial Manager

Centessa Pharmaceuticals, LLC•Boston, MA

6h•Remote

About The Position

Centessa is seeking a Clinical Trial Manager (CTM) to lead the execution of mid- to late-stage global clinical studies from study start-up through close-out and clinical study report. The CTM is responsible for day-to-day trial management, coordinating internal cross-functional teams and overseeing CROs and external vendors to ensure studies are delivered on time, within budget, and in compliance with quality and regulatory standards. This role requires hands-on involvement in clinical trial execution, proactive identification and resolution of operational issues, and accountability for study performance metrics and deliverable quality. The CTM also contributes to operational planning, risk assessment, and continuous process improvement in collaboration with study team leadership.

Requirements

Bachelor’s degree in a scientific or health‑related discipline.
5+ years clinical trial management experience within an industry sponsor environment, supporting drug development programs.
Proven ability to manage global clinical studies, including coordination with investigators, CROs, and functional vendors.
Strong working knowledge of ICH guidelines, GCP, and global regulatory requirements applicable to clinical trials.
Solid understanding of project management principles, including planning and managing timelines, resources, budgets, and risk–benefit trade‑offs
Excellent communication, collaboration, and interpersonal skills, with the ability to influence without formal authority and drive cross‑functional team performance.
Demonstrated ability to manage multiple priorities in a fast‑paced environment, meeting aggressive timelines while maintaining quality.
Proactive problem‑solving mindset with the ability to anticipate issues, identify creative solutions, and take initiative to address risks impacting timelines or budgets.

Nice To Haves

Experience managing clinical trials in CNS therapeutic development strongly preferred.
PMP or similar training is a plus.

Responsibilities

Plan and execute mid‑ to late‑stage CNS clinical trials from study start‑up through close‑out, ensuring operational excellence, high data quality, and compliance with protocol, GCP, and global regulatory requirements.
Lead day‑to‑day clinical trial operations, coordinating cross‑functional partners (Clinical Development, Data Management, Biostatistics, Regulatory, Safety) to ensure efficient trial execution and alignment to program objectives.
Oversee CROs and external vendors supporting CNS clinical trials, including co‑monitoring activities, to ensure delivery against scope of work, timelines, budget, and quality expectations.
Drive critical study milestones, including site activation, enrollment progress, patient retention, data cleaning, and database lock, proactively addressing operational challenges common to CNS trials.
Review and approve CRO‑ and vendor‑generated plans and study documentation, ensuring alignment with protocol, regulatory expectations, and Centessa quality standards.
Monitor study progress and performance using operational metrics and tools, maintaining dashboards, timelines, and financial tracking, and providing clear, timely status updates to study teams and management.
Identify, assess, and manage operational risks, proposing practical mitigation strategies and supporting informed decision‑making to minimize impact to timelines, quality, and patient safety.
Ensure inspection and audit readiness, including oversight of Trial Master File (TMF) set‑up, ongoing maintenance, and close‑out for CNS studies.
Contribute to operational planning and regulatory deliverables, supporting preparation of study‑level documentation for Health Authority interactions and continuous improvement of clinical operations processes.