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The Senior Clinical Trial Manager will serve as the primary point of contact (POC) for US sites, supporting study follow-up and data clean-up. This role involves collaboration with the Lead CTM and EU CTM to ensure cohesive trial management. The manager will oversee vendor operations, including central labs, imaging, and shipments, while maintaining continuous site interaction, effective site management, and budget adherence. Additionally, the role requires working closely with Key Opinion Leaders (KOLs) and managing the complexities of combination devices within the trial.