Clinical Digital & AI Acceleration Portfolio Manager

Sanofi • Cambridge, MA

30d

About The Position

CSO Digital Transformation is a flagship, multi-year transformation program designed to fundamentally modernize Sanofi’s clinical operations through the scaled adoption of digital technologies, data, and Artificial Intelligence. The portfolio spans site and patient engagement, operational acceleration (including clinical supply chains), real-time data access, and AI-enabled operations and decision support, with a strong emphasis on measurable business and patient impact. The Clinical Digital & AI Acceleration Portfolio Manager is a senior strategic partner to the Head of Clinical Digital & AI Acceleration. Unlike a traditional PMO role, this position orchestrates the end-to-end transformation portfolio from strategy to value realization, ensuring that initiatives are prioritized, integrated, governed, and scaled in line with CSO and Sanofi enterprise objectives. This role interfaces with executive sponsors, program leaders, finance, and business capability owners to ensure that programs and projects deliver tangible outcomes, quantified value, and sustainable adoption, supported by robust digital portfolio performance intelligence, dashboards and insights.

Requirements

• Minimum 7+ years in project and portfolio management, with demonstrated exposure to large-scale transformation or modernization programs
• Proven experience driving digital, data, or AI-enabled transformation in complex organizations
• Strong command of portfolio governance, value-based prioritization, and performance tracking
• Solid experience with business case development, ROI modeling, and financial steering
• Demonstrated ability to partner with senior leaders and influence without direct authority
• Experience in matrixed, global environments requiring orchestration across functions
• Strategic and systems thinker, able to connect initiatives into a coherent transformation narrative
• Strong analytical skills paired with business-oriented judgment
• Credible, calm leadership presence in executive settings
• Change/modernization-oriented mindset, comfortable challenging the status quo
• Excellent cross-cultural collaboration and communication skills
• Bachelors required.

Nice To Haves

• Master's degree or PhD preferred.
• Experience in digital audit is a plus

Responsibilities

• Strategic Portfolio Alignment & Modernization: Continuously align portfolio components with Sanofi’s strategy and CSO priorities, ensuring a clear line of sight between transformation investments and business outcomes
• Shape and challenge the portfolio strategy by developing scenarios that support executive decision-making, trade-offs, and prioritization
• Identify cross-initiative synergies, reuse opportunities, and integration levers to avoid siloed digital initiatives
• Translate modernization ambitions (digital, data, AI) into executable, value-driven roadmaps
• Actively identify new modernization opportunities across clinical operations, informed by performance data, capability gaps, and emerging technologies
• Portfolio Governance & Operating Model Coordinate, evolve and professionalize the Initiative Portfolio Management Office (iPMO) as a strategic governance layer, not only a control mechanism
• Define and maintain governance standards covering value hypotheses, ROI tracking, adoption readiness, and scale-up criteria
• Coach and challenge program teams on business case quality, value articulation, and outcome-based delivery
• Ensure alignment with Digital, eDEV, and CSO innovation governance, including integration of externally incubated or “off-the-shelf” solutions
• Act as a modernization thought partner rather than a purely procedural PMO
• Portfolio Performance & Value Management: Own the definition and consolidation of portfolio-level KPIs, including value realization, adoption, maturity, and transformation impact
• Monitor portfolio health using decision-grade performance intelligence (progress, risks, interdependencies, value delivery)
• Proactively identify risks, bottlenecks, and underperforming initiatives, and recommend corrective or reprioritization actions
• Ensure robust transition to business and establish and maintain a framework for visibility of transition to business and scale-up, tracking whether initiatives deliver value beyond pilot phases
• Produce executive-level insights and narratives linking digital transformation to tangible CSO outcomes
• Manage complex transformation program as needed
• Financial Strategy & Value Realization: Partner with Finance and OPCM to drive disciplined investment management across the portfolio
• Ensure initiatives are supported by clear financial logic (ROI, cost avoidance, productivity gains, quality or cycle-time impact)
• Track financial performance across the lifecycle, from investment decision to realized value
• Support budget cycles and financial milestones with credible, evidence-based portfolio insights
• Strategic Resource & Capability Alignment Assess and consolidate portfolio-level resource needs, with a focus on critical capabilities rather than just capacity
• Optimize resource allocation across initiatives to maximize portfolio throughput and value
• Support vendor strategy, sourcing decisions, and contract governance in alignment with transformation priorities, and ensure up-to-date tracking of external resource allocation
• Identify capability gaps (digital, data, AI, change) and propose targeted upskilling or sourcing solutions
• Ensure coherent onboarding and enablement of teams across programs
• Executive Communication & Stakeholder Engagement Design and execute high-impact portfolio presentations, reports and communications for CSO leadership (SLT, deep dives, executive reviews, etc)
• Act as a trusted interlocutor for MPO leader and senior stakeholders, balancing competing priorities and perspectives
• Translate complex transformation topics into clear, outcome-oriented executive narratives
• Deliver concise, insight-driven monthly portfolio reports highlighting progress, deployment, value, risks, and decisions required

Benefits

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level