Clinical Biomarker Lead

Janux Therapeutics • San Diego, CA

4d • $150,000 - $163,000 • Onsite

About The Position

Janux Therapeutics is seeking a Clinical Biomarker Lead to join our Translational group and contribute hands-on in the development and execution of biomarker analysis plans and data analytics strategy for our early-stage oncology programs. This individual will develop critical insights from clinical trial data to inform strategic decision-making across Janux’s early phase portfolio. The ideal candidate will bring an in-depth understanding of solid tumor immunology and clinical-translational research experience.

Requirements

• Ph.D. in Bioinformatics, Computational Biology, Immunology, or related scientific discipline with 4+ years of experience, preferably in an industry setting, with an emphasis in biomarker analysis or translational medicine.
• Strong understanding and experience working in immuno-oncology and/or solid tumor oncology with hands-on experience in designing, developing, and interpreting biomarker analysis.
• Proficiency in coding skills (e.g., R, Python) and strong working knowledge of bioinformatics databases and tools.
• Demonstrated ability to create impactful data visualization outputs and present meaningful insights.
• Experience with Good Clinical Practice (GCP) principles and studies transitioning into clinical trials.
• Competence in data analysis tools (Excel, GraphPad, R, Python).
• Strong analytical and critical thinking skills with the ability to work in a fast-paced environment. Excellent written and oral communication skills.

Nice To Haves

• Experience working with external CROs (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly preferred.

Responsibilities

• Lead internal biomarker data analysis efforts to support Janux’s oncology and autoimmune pipeline.
• Perform high throughput data analytics of pre-clinical, translational, and clinical datasets to identify and validate potential biomarkers of response/resistance to TRACTr, TRACIr, and/or ARM treatments.
• Integrate functional biological readouts with patient’s clinicopathological features to contribute to patient selection strategies for clinical programs.
• Identify, develop, and validate translational and clinical biomarker assays including Pharmacokinetics, immunogenicity (ADA and NAb assays), Pharmacodynamics, and predictive.
• Manage multiple CROs and maintain strong oversight on deliverables (proposals, timelines, experimental design, data analyses and reporting).
• Prepare and present data. Collaborate with Biomarker and Translational teams to evaluate data analytic approaches and ensure meaningful insights in the delivery.
• Perform in-depth scientific literature review to help address critical questions relating to target biology, clinical relevance, and associated assays.
• Work cross-functionally with Research, Clinical and CMC teams to drive scientific programs and deliver critical insights to help inform decision-making across the portfolio.

Benefits

• Annual bonus program
• Incentive stock option plan
• 401k plan with flat non-elective employer contribution
• Comprehensive medical insurance with 90-100% employer-paid premiums
• Dental and vision insurance
• HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
• Unlimited PTO
• Generous holiday schedule; includes summer and winter company shutdown
• Relocation assistance

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 101-250 employees